3DLE

Crystal structure of hiv-1 reverse transcriptase in complex with GF128590.

Summary for 3DLE

• Entry DOI: 10.2210/pdb3dle/pdb
• Related: 3DLG
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 2-[4-chloro-2-(phenylcarbonyl)phenoxy]-N-phenylacetamide, ... (4 entities in total)
• Functional Keywords: hiv-1 reverse transcriptase, aids, nnrti, gf128590, drug resistance, hydrolase, transferase
• Biological source: HIV-1 M:B_HXB2R (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116359.81

Authors

Ren, J.,Chamberlain, P.P.,Stammers, D.K. (deposition date: 2008-06-27, release date: 2008-08-12, Last modification date: 2011-07-13)

• Primary citation: Ren, J.,Chamberlain, P.P.,Stamp, A.,Short, S.A.,Weaver, K.L.,Romines, K.R.,Hazen, R.,Freeman, A.,Ferris, R.G.,Andrews, C.W.,Boone, L.,Chan, J.H.,Stammers, D.K.; Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.; J.Med.Chem., 51:5000-5008, 2008; PubMed: 18665583; DOI: 10.1021/jm8004493

Experimental method

X-RAY DIFFRACTION (2.5 Å)