HIV-1 Reverse Transcriptase in Complex with TMC278

Summary for 3MEE
Related3MEC 3MED 3MEG
Descriptorp66 Reverse transcriptase, p51 Reverse transcriptase, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (5 entities in total)
Functional Keywordshiv, reverse transcriptase, tmc278, rilpivirine, nnrti, transferase
Biological sourceHIV-1 M:B_HXB2R (HIV-1)
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains2
Total formula weight116808.73
Lansdon, E.B. (deposition date: 2010-03-31, release date: 2010-05-12, Last modification date: 2015-06-17)
Primary citationBirkus, G.,Brendza, K.M.,Hung, M.,Jin, D.,Kutty, N.,Lansdon, E.B.,Liu, X.,Mukund, S.,Wang, R.
Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.
J.Med.Chem., 53:4295-4299, 2010
PubMed: 20438081
DOI: 110.1021/jm1002233
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-09