3MED
HIV-1 K103N Reverse Transcriptase in Complex with TMC125
Summary for 3MED
Entry DOI | 10.2210/pdb3med/pdb |
Related | 3MEC 3MEE 3MEG |
Descriptor | p66 Reverse transcriptase, p51 Reverse transcriptase, 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, ... (6 entities in total) |
Functional Keywords | hiv, reverse transcriptase, tmc125, etravirine, nnrti, transferase |
Biological source | HIV-1 M:B_HXB2R (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116978.95 |
Authors | Lansdon, E.B. (deposition date: 2010-03-31, release date: 2010-05-12, Last modification date: 2023-09-06) |
Primary citation | Lansdon, E.B.,Brendza, K.M.,Hung, M.,Wang, R.,Mukund, S.,Jin, D.,Birkus, G.,Kutty, N.,Liu, X. Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design. J.Med.Chem., 53:4295-4299, 2010 Cited by PubMed: 20438081DOI: 10.1021/jm1002233 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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