3MED
HIV-1 K103N Reverse Transcriptase in Complex with TMC125
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | p66 Reverse transcriptase | polymer | 560 | 64547.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | HIV-1 M:B_HXB2R (HIV-1) | |
| 2 | B | p51 Reverse transcriptase | polymer | 440 | 51384.0 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | HIV-1 M:B_HXB2R (HIV-1) | |
| 3 | A | 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE | non-polymer | 435.3 | 1 | Chemie (65B) | |||
| 4 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Asn 103 | Lys 690 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 103 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 115931.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1047.1 | |
| All* | Total formula weight | 116978.9 |
