3MEC

HIV-1 Reverse Transcriptase in Complex with TMC125

Summary for 3MEC

• Entry DOI: 10.2210/pdb3mec/pdb
• Related: 3MED 3MEE 3MEG
• Descriptor: p66 Reverse transcriptase, p51 Reverse transcriptase, 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, ... (5 entities in total)
• Functional Keywords: hiv, reverse transcriptase, tmc125, etravirine, nnrti, transferase
• Biological source: HIV-1 M:B_HXB2R (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116877.59

Authors

Lansdon, E.B. (deposition date: 2010-03-31, release date: 2010-05-12, Last modification date: 2023-09-06)

• Primary citation: Lansdon, E.B.,Brendza, K.M.,Hung, M.,Wang, R.,Mukund, S.,Jin, D.,Birkus, G.,Kutty, N.,Liu, X.; Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.; J.Med.Chem., 53:4295-4299, 2010; PubMed: 20438081; DOI: 10.1021/jm1002233

Experimental method

X-RAY DIFFRACTION (2.3 Å)