3MEC

HIV-1 Reverse Transcriptase in Complex with TMC125

Summary for 3MEC
Related3MED 3MEE 3MEG
Descriptorp66 Reverse transcriptase, p51 Reverse transcriptase, 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, ... (5 entities in total)
Functional Keywordshiv, reverse transcriptase, tmc125, etravirine, nnrti, transferase
Biological sourceHIV-1 M:B_HXB2R (HIV-1)
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116877.59
Authors
Lansdon, E.B. (deposition date: 2010-03-31, release date: 2010-05-12, Last modification date: 2012-07-18)
Primary citationBirkus, G.,Brendza, K.M.,Hung, M.,Jin, D.,Kutty, N.,Lansdon, E.B.,Liu, X.,Mukund, S.,Wang, R.
Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.
J.Med.Chem., 53:4295-4299, 2010
PubMed: 20438081
DOI: 110.1021/jm1002233
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-09