3DLG

Crystal structure of hiv-1 reverse transcriptase in complex with GW564511.

Summary for 3DLG
Related3DLE
DescriptorREVERSE TRANSCRIPTASE/RIBONUCLEASE H, P51 RT, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, nnrti, gw564511, drug resistance, transferase, hydrolase
Biological sourceHIV-1 M:B_HXB2R (HIV-1)
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116730.86
Authors
Ren, J.,Chamberlain, P.P.,Stammers, D.K. (deposition date: 2008-06-27, release date: 2008-08-12, Last modification date: 2011-07-13)
Primary citationAndrews, C.W.,Boone, L.,Chamberlain, P.P.,Chan, J.H.,Ferris, R.G.,Freeman, A.,Hazen, R.,Ren, J.,Romines, K.R.,Short, S.A.,Stammers, D.K.,Stamp, A.,Weaver, K.L.
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J.Med.Chem., 51:5000-5008, 2008
PubMed: 18665583
DOI: 110.1021/jm8004493
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation
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PDB entries from 2021-06-09