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6CP9
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Contact-dependent growth inhibition toxin - immunity protein complex from Klebsiella pneumoniae 342
分子名称: CdiA, CdiI
著者Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
登録日2018-03-13
公開日2019-03-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.
Structure, 27, 2019
5C73
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ATP-driven lipid-linked oligosaccharide flippase PglK in outward-occluded conformation
分子名称: Protein glycosylation K
著者Perez, C, Locher, K.P.
登録日2015-06-24
公開日2015-08-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (5.9 Å)
主引用文献Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
5C78
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ATP-driven lipid-linked oligosaccharide flippase PglK in apo-inward state (1)
分子名称: ATP-driven flippase PglK, PENTAETHYLENE GLYCOL
著者Perez, C, Locher, K.P.
登録日2015-06-24
公開日2015-08-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure and mechanism of an active lipid-linked oligosaccharide flippase.
Nature, 524, 2015
1KZX
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Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T)
分子名称: INTESTINAL FATTY ACID-BINDING PROTEIN (T54)
著者Zhang, F, Luecke, C, Baier, L.J, Sacchettini, J.C, Hamilton, J.A.
登録日2002-02-08
公開日2003-07-01
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism
Biochemistry, 42, 2003
6CP8
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BU of 6cp8 by Molmil
Contact-dependent growth inhibition toxin-immunity protein complex from from E. coli 3006
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CdiA, CdiI, ...
著者Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)
登録日2018-03-13
公開日2019-03-13
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.
Structure, 27, 2019
7ZVA
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Crystal Structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 A resolution.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, C-terminal peptidase, ...
著者Del Amo-Maestro, L, Eckhard, U, Rodriguez-Banqueri, A, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X.
登録日2022-05-14
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.
Nat Commun, 13, 2022
7ZU8
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Crystal Structure of the zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 2.05 A resolution in presence of the crystallophore Lu-Xo4.
分子名称: 12-oxidanyl-9,11$l^{3}-dioxa-1$l^{4},19$l^{4},22,27$l^{4},28$l^{4}-pentaza-10$l^{6}-lutetaoctacyclo[17.5.2.1^{3,7}.1^{10,13}.0^{1,10}.0^{10,19}.0^{10,28}.0^{17,27}]octacosa-3,5,7(28),11,13,15,17(27)-heptaen-8-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Del Amo-Maestro, L, Eckhard, U, Rodriguez-Banqueri, A, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X.
登録日2022-05-11
公開日2022-08-10
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.
Nat Commun, 13, 2022
5DUO
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Crystal structure of native translocator protein 18kDa (TSPO) from Rhodobacter sphaeroides (A139T Mutant) in C2 space group
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FORMIC ACID, PROTOPORPHYRIN IX, ...
著者Li, F, Liu, J, Zheng, Y, Garavito, R.M, Ferguson-Miller, S.
登録日2015-09-20
公開日2015-11-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Response to Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism".
Science, 350, 2015
5BTQ
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Crystal structure of human heme oxygenase 1 H25R with biliverdin bound
分子名称: BILIVERDINE IX ALPHA, Heme oxygenase 1, SULFATE ION
著者Caaveiro, J.M.M, Morante, K, Sigala, P, Tsumoto, K.
登録日2015-06-03
公開日2016-06-08
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis
Biochemistry, 55, 2016
5E5J
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BU of 5e5j by Molmil
Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with darunavir at pH 6.0
分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease
著者Kovalevsky, A.Y, Gerlits, O.O.
登録日2015-10-08
公開日2016-05-04
最終更新日2024-03-06
実験手法NEUTRON DIFFRACTION (1.85 Å), X-RAY DIFFRACTION
主引用文献Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.
Angew.Chem.Int.Ed.Engl., 55, 2016
1LW6
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BU of 1lw6 by Molmil
Crystal Structure of the Complex of Subtilisin BPN' with Chymotrypsin Inhibitor 2 at 1.5 Angstrom Resolution
分子名称: CALCIUM ION, SUBTILISIN BPN', SUBTILISIN-CHYMOTRYPSIN INHIBITOR-2A, ...
著者Radisky, E.S, Koshland JR, D.E.
登録日2002-05-30
公開日2002-08-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A clogged gutter mechanism for protease inhibitors.
Proc.Natl.Acad.Sci.USA, 99, 2002
3IKY
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BU of 3iky by Molmil
Structural model of ParM filament in the open state by cryo-EM
分子名称: Plasmid segregation protein parM
著者Galkin, V.E, Orlova, A, Rivera, C, Mullins, R.D, Egelman, E.H.
登録日2009-08-06
公開日2009-09-29
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (18 Å)
主引用文献Structural polymorphism of the ParM filament and dynamic instability
Structure, 17, 2009
3IKU
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BU of 3iku by Molmil
Structural model of ParM filament in closed state from cryo-EM
分子名称: Plasmid segregation protein parM
著者Galkin, V.E, Orlova, A, Rivera, C, Mullins, R.D, Egelman, E.H.
登録日2009-08-06
公開日2009-09-29
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (18 Å)
主引用文献Structural polymorphism of the ParM filament and dynamic instability
Structure, 17, 2009
4IIS
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BU of 4iis by Molmil
Crystal structure of a glycosylated beta-1,3-glucanase (HEV B 2), An allergen from Hevea Brasiliensis (Space group P41)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-1,3-glucanase form 'RRII Gln 2', CACODYLATE ION, ...
著者Rodriguez-Romero, A, Hernandez-Santoyo, A.
登録日2012-12-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6676 Å)
主引用文献Structural analysis of the endogenous glycoallergen Hev b 2 (endo-beta-1,3-glucanase) from Hevea brasiliensis and its recognition by human basophils.
Acta Crystallogr.,Sect.D, 70, 2014
2AIH
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BU of 2aih by Molmil
1H-NMR solution structure of a trypsin/chymotrypsin Bowman-Birk inhibitor from Lens culinaris.
分子名称: Bowman-Birk type protease inhibitor, LCTI, CHLORIDE ION
著者Ragg, E.M, Galbusera, V, Scarafoni, A, Negri, A, Tedeschi, G, Consonni, A, Sessa, F, Duranti, M.
登録日2005-07-29
公開日2006-08-01
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Inhibitory properties and solution structure of a potent Bowman-Birk protease inhibitor from lentil (Lens culinaris, L) seeds.
Febs J., 273, 2006
4I04
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BU of 4i04 by Molmil
Structure of zymogen of cathepsin B1 from Schistosoma mansoni
分子名称: 1,2-ETHANEDIOL, Cathepsin B-like peptidase (C01 family)
著者Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M.
登録日2012-11-16
公開日2014-02-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch
Structure, 22, 2014
3VY6
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Crystal structure of human pancreatic secretory protein ZG16p with laminaribiose
分子名称: CHLORIDE ION, Zymogen granule membrane protein 16, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose
著者Kanagawa, M, Yamaguchi, Y.
登録日2012-09-21
公開日2013-09-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin
J.Biol.Chem., 289, 2014
3QVC
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Crystal structure of histo-aspartic protease (HAP) zymogen from Plasmodium falciparum
分子名称: 1,2-ETHANEDIOL, Histo-aspartic protease
著者Bhaumik, P, Gustchina, A, Wlodawer, A.
登録日2011-02-25
公開日2011-10-12
最終更新日2011-11-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum.
Biochemistry, 50, 2011
3VZF
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BU of 3vzf by Molmil
Crystal structure of human pancreatic secretory protein ZG16p with methyl alpha-D-mannopyranoside
分子名称: CHLORIDE ION, Zymogen granule membrane protein 16, methyl alpha-D-mannopyranoside
著者Kanagawa, M, Yamaguchi, Y.
登録日2012-10-11
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin
J.Biol.Chem., 289, 2014
3VZG
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Crystal structure of human pancreatic secretory protein ZG16p with O-(alpha-D-mannosyl)-L-threonine
分子名称: CHLORIDE ION, THREONINE, Zymogen granule membrane protein 16, ...
著者Kanagawa, M, Yamaguchi, Y.
登録日2012-10-11
公開日2013-10-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin
J.Biol.Chem., 289, 2014
3VY7
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Crystal structure of human pancreatic secretory protein ZG16p with O-(alpha-D-mannosyl)-L-serine
分子名称: CHLORIDE ION, SERINE, Zymogen granule membrane protein 16, ...
著者Kanagawa, M, Yamaguchi, Y.
登録日2012-09-21
公開日2013-09-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin
J.Biol.Chem., 289, 2014
6TL2
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Crystal structure of Eremococcus coleocola manganese transporter in complex with an aromatic bis-isothiourea substituted compound
分子名称: Divalent metal cation transporter MntH, [3-bromanyl-5-(carbamimidoylsulfanylmethyl)phenyl]methyl carbamimidothioate
著者Manatschal, C, Dutzler, R.
登録日2019-11-29
公開日2019-12-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.
Elife, 8, 2019
6SV2
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Human prion protein (PrP) fragment 119-231 (G127V M129 variant) complexed to ICSM 18 (anti-Prp therapeutic antibody) Fab fragment
分子名称: ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN, Major prion protein, ...
著者Conners, R.
登録日2019-09-17
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural effects of the highly protective V127 polymorphism on human prion protein.
Commun Biol, 3, 2020
6SUZ
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BU of 6suz by Molmil
Human prion protein (PrP) fragment 119-231 (G127V V129 variant) complexed to ICSM 18 (anti-Prp therapeutic antibody) Fab fragment
分子名称: ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN, Major prion protein, ...
著者Conners, R.
登録日2019-09-17
公開日2020-08-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural effects of the highly protective V127 polymorphism on human prion protein.
Commun Biol, 3, 2020
5OI8
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Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
分子名称: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-4-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, Pol protein, ...
著者Ruff, M, Benarous, R.
登録日2017-07-18
公開日2018-03-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J. Biol. Chem., 293, 2018

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