7ZVA

Crystal Structure of the native zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 1.80 A resolution.

Summary for 7ZVA

• Entry DOI: 10.2210/pdb7zva/pdb
• Related: 7ZU8
• Descriptor: C-terminal peptidase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: glutamic endopeptidase, zymogen, proform, coeliac disease therapy, plant protease, hydrolase
• Biological source: Nepenthes ventricosa x Nepenthes alata
• Total number of polymer chains: 1
• Total formula weight: 44791.37

Authors

Del Amo-Maestro, L.,Eckhard, U.,Rodriguez-Banqueri, A.,Mendes, S.R.,Guevara, T.,Gomis-Ruth, F.X. (deposition date: 2022-05-14, release date: 2022-08-10, Last modification date: 2024-01-31)

• Primary citation: Del Amo-Maestro, L.,Mendes, S.R.,Rodriguez-Banqueri, A.,Garzon-Flores, L.,Girbal, M.,Rodriguez-Lagunas, M.J.,Guevara, T.,Franch, A.,Perez-Cano, F.J.,Eckhard, U.,Gomis-Ruth, F.X.; Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.; Nat Commun, 13:4446-4446, 2022; PubMed: 35915115; DOI: 10.1038/s41467-022-32215-1

Experimental method

X-RAY DIFFRACTION (1.8 Å)