6SV2

Human prion protein (PrP) fragment 119-231 (G127V M129 variant) complexed to ICSM 18 (anti-Prp therapeutic antibody) Fab fragment

Summary for 6SV2

• Entry DOI: 10.2210/pdb6sv2/pdb
• Related: 6SUZ
• Descriptor: ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN, Major prion protein, ... (5 entities in total)
• Functional Keywords: prion, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 59699.12

Authors

Conners, R. (deposition date: 2019-09-17, release date: 2020-07-29, Last modification date: 2024-01-24)

• Primary citation: Hosszu, L.L.P.,Conners, R.,Sangar, D.,Batchelor, M.,Sawyer, E.B.,Fisher, S.,Cliff, M.J.,Hounslow, A.M.,McAuley, K.,Leo Brady, R.,Jackson, G.S.,Bieschke, J.,Waltho, J.P.,Collinge, J.; Structural effects of the highly protective V127 polymorphism on human prion protein.; Commun Biol, 3:402-402, 2020; PubMed: 32728168; DOI: 10.1038/s42003-020-01126-6

Experimental method

X-RAY DIFFRACTION (2.3 Å)