7ZU8

Crystal Structure of the zymogen form of the glutamic-class prolyl-endopeptidase neprosin at 2.05 A resolution in presence of the crystallophore Lu-Xo4.

Summary for 7ZU8

Entry DOI	10.2210/pdb7zu8/pdb
Descriptor	Glutamyl endopeptidase Neprosin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	glutamic endopeptidase, zymogen, proform, coeliac disease therapy, crystallophore, hydrolase
Biological source	Nepenthes ventricosa x Nepenthes alata
Total number of polymer chains	1
Total formula weight	45266.54
Authors	Del Amo-Maestro, L.,Eckhard, U.,Rodriguez-Banqueri, A.,Mendes, S.R.,Guevara, T.,Gomis-Ruth, F.X. (deposition date: 2022-05-11, release date: 2022-08-10)
Primary citation	Del Amo-Maestro, L.,Mendes, S.R.,Rodriguez-Banqueri, A.,Garzon-Flores, L.,Girbal, M.,Rodriguez-Lagunas, M.J.,Guevara, T.,Franch, A.,Perez-Cano, F.J.,Eckhard, U.,Gomis-Ruth, F.X. Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy. Nat Commun, 13:4446-4446, 2022 Cited by PubMed: 35915115 DOI: 10.1038/s41467-022-32215-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation