4KXU
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![BU of 4kxu by Molmil](/molmil-images/mine/4kxu) | Human transketolase in covalent complex with donor ketose D-fructose-6-phosphate | 分子名称: | 1,2-ETHANEDIOL, D-SORBITOL-6-PHOSPHATE, MAGNESIUM ION, ... | 著者 | Neumann, P, Luedtke, S, Ficner, R, Tittmann, K. | 登録日 | 2013-05-28 | 公開日 | 2013-08-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem, 5, 2013
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4L6I
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![BU of 4l6i by Molmil](/molmil-images/mine/4l6i) | Methylthioadenosine phosphorylase from Schistosoma mansoni in complex with adenine | 分子名称: | ADENINE, S-methyl-5'-thioadenosine phosphorylase, SULFATE ION | 著者 | Torini, J.R, DeMarco, R, Brandao-Neto, J, Pereira, H.M. | 登録日 | 2013-06-12 | 公開日 | 2014-06-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway. Plos Negl Trop Dis, 10, 2016
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3HIH
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![BU of 3hih by Molmil](/molmil-images/mine/3hih) | |
3HIO
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![BU of 3hio by Molmil](/molmil-images/mine/3hio) | Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue | 分子名称: | 9,9'-{(2R,3R,3aR,5S,7aR,9R,10R,10aR,12S,23R,25aR,27R,28R,28aR,30S,32aR,35aR,37S,39aR)-9-(6-amino-9H-purin-9-yl)-34-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5,12,23,30,37-pentahydroxy-3,10,28-trimethoxy-5,12,23,30,37-pentaoxidotetracosahydro-2H,7H,25H-trifuro[3,2-f:3',2'-l:3'',2''-x]pyrrolo[3,4-r][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]undecaoxazapentaphosphacyclopentatriacontine-2,27-diyl}bis(2-amino-3,9-dihydro-6H-purin-6-one), Ricin, SULFATE ION | 著者 | Ho, M, Sturm, M.B, Goldman, J.D, Almo, S.C, Schramm, V.L. | 登録日 | 2009-05-20 | 公開日 | 2009-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106, 2009
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3HIM
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![BU of 3him by Molmil](/molmil-images/mine/3him) | The Crystal Structure of a Bacterial Regulatory Protein in the tetR Family from Rhodococcus RHA1 to 2.2A | 分子名称: | Probable transcriptional regulator | 著者 | Stein, A.J, Binkowski, T.A, Evdokimova, E, Kagan, O, Edwards, A, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2009-05-20 | 公開日 | 2009-05-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Crystal Structure of a Bacterial Regulatory Protein in the tetR Family from Rhodococcus RHA1 to 2.2A To be Published
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4KZ7
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![BU of 4kz7 by Molmil](/molmil-images/mine/4kz7) | Crystal structure of AmpC beta-lactamase in complex with fragment 16 ((1R,4S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid) | 分子名称: | (1R,4S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Eidam, O, Barelier, S, Fish, I, Shoichet, B.K. | 登録日 | 2013-05-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Increasing chemical space coverage by combining empirical and computational fragment screens. Acs Chem.Biol., 9, 2014
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3HIZ
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![BU of 3hiz by Molmil](/molmil-images/mine/3hiz) | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Amzel, L.M, Vogelstein, B, Gabelli, S.B, Mandelker, D. | 登録日 | 2009-05-20 | 公開日 | 2009-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106, 2009
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4PT4
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![BU of 4pt4 by Molmil](/molmil-images/mine/4pt4) | Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Ra] | 分子名称: | DNA-binding protein HU homolog, FORMIC ACID | 著者 | Bhowmick, T, Ramagopal, U.A, Ghosh, S, Nagaraja, V, Ramakumar, S. | 登録日 | 2014-03-10 | 公開日 | 2014-05-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors Nat Commun, 5, 2014
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2EMQ
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2OVC
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3QD3
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![BU of 3qd3 by Molmil](/molmil-images/mine/3qd3) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... | 著者 | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | 登録日 | 2011-01-17 | 公開日 | 2011-03-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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3QHB
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2OVH
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![BU of 2ovh by Molmil](/molmil-images/mine/2ovh) | Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT | 分子名称: | 4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE OXIME, Progesterone receptor, SMRT peptide | 著者 | Madauss, K.P, Deng, S.-J, Short, S.A, Stewart, E.L, Williams, S.P. | 登録日 | 2007-02-13 | 公開日 | 2007-03-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. Mol.Endocrinol., 21, 2007
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4KV0
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3HDZ
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![BU of 3hdz by Molmil](/molmil-images/mine/3hdz) | Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors | 分子名称: | 5-amino-1-butyl-7-phenyl-1,6-naphthyridin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Cubbage, J.W, Brown, D.G, Jacobsen, E.J, Walker, J.K, Hughes, R.O. | 登録日 | 2009-05-07 | 公開日 | 2009-07-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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3HHM
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![BU of 3hhm by Molmil](/molmil-images/mine/3hhm) | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin | 分子名称: | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Amzel, L.M, Vogelstein, B, Gabelli, S.B, Mandelker, D. | 登録日 | 2009-05-15 | 公開日 | 2009-09-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106, 2009
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3HFD
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3QEQ
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2P2M
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![BU of 2p2m by Molmil](/molmil-images/mine/2p2m) | Acetyl-CoA Synthetase, R194A mutation | 分子名称: | ADENOSINE-5'-MONOPHOSPHATE-PROPYL ESTER, Acetyl-coenzyme A synthetase | 著者 | Reger, A.S, Gulick, A.M. | 登録日 | 2007-03-07 | 公開日 | 2007-05-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase. Biochemistry, 46, 2007
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4KY2
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![BU of 4ky2 by Molmil](/molmil-images/mine/4ky2) | Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one | 分子名称: | 7-hydroxy-3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]-4-methyl-2H-chromen-2-one, Transthyretin | 著者 | Connelly, S, Wilson, I.A, Choi, S. | 登録日 | 2013-05-28 | 公開日 | 2013-08-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chem.Commun.(Camb.), 49, 2013
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2OX7
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![BU of 2ox7 by Molmil](/molmil-images/mine/2ox7) | Crystal structure of protein EF1440 from Enterococcus faecalis | 分子名称: | Hypothetical protein | 著者 | Malashkevich, V.N, Toro, R, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Bain, K.T, Adams, J.M, Reyes, C, Lau, C, Gilmore, J, Rooney, I, Gheyi, T, Wasserman, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2007-02-19 | 公開日 | 2007-03-06 | 最終更新日 | 2021-02-03 | 実験手法 | X-RAY DIFFRACTION (1.777 Å) | 主引用文献 | Crystal structure of the hypothetical protein from Enterococcus faecalis To be Published
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4KVB
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4KY5
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![BU of 4ky5 by Molmil](/molmil-images/mine/4ky5) | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D at pH 7 and cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Robinson, A.C, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. | 登録日 | 2013-05-28 | 公開日 | 2013-06-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D at pH 7 and cryogenic temperature To be Published
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3HGD
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3QFJ
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![BU of 3qfj by Molmil](/molmil-images/mine/3qfj) | The complex between TCR A6 and human Class I MHC HLA-A2 with the modified TAX (Y5F) peptide | 分子名称: | A6 alpha chain, A6 beta chain, Beta-2-microglobulin, ... | 著者 | Borbulevych, O.Y, Baker, B.M. | 登録日 | 2011-01-21 | 公開日 | 2012-01-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism. J.Mol.Biol., 414, 2011
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