4PT4

Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Ra]

Replaces:  3C4I

Summary for 4PT4

• Entry DOI: 10.2210/pdb4pt4/pdb
• Related: 4DKY
• Descriptor: DNA-binding protein HU homolog, FORMIC ACID (3 entities in total)
• Functional Keywords: dimerization by four helix bundle interaction, dna condensation, dna-binding, dna binding protein
• Biological source: Mycobacterium tuberculosis H37Ra
• Total number of polymer chains: 2
• Total formula weight: 21528.53

Authors

Bhowmick, T.,Ramagopal, U.A.,Ghosh, S.,Nagaraja, V.,Ramakumar, S. (deposition date: 2014-03-10, release date: 2014-05-21, Last modification date: 2023-11-08)

• Primary citation: Bhowmick, T.,Ghosh, S.,Dixit, K.,Ganesan, V.,Ramagopal, U.A.,Dey, D.,Sarma, S.P.,Ramakumar, S.,Nagaraja, V.; Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors; Nat Commun, 5:4124-4124, 2014; PubMed: 24916461; DOI: 10.1038/ncomms5124

Experimental method

X-RAY DIFFRACTION (2.04 Å)