3QEQ
The complex between TCR DMF4 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide
Summary for 3QEQ
Entry DOI | 10.2210/pdb3qeq/pdb |
Related | 3QDG 3QDJ 3QDM 3QEU |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, MART-1(27-35) peptide, ... (6 entities in total) |
Functional Keywords | mart-1 peptide, nonapeptide, mhc class i, hla-a2, tcr dmf5, tcr dmf4, cross-reactivity, cancer, melanoma, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted . Note=(Microbial infection) In the presence of M: P61769 |
Total number of polymer chains | 5 |
Total formula weight | 93346.43 |
Authors | Borbulevych, O.Y.,Baker, B.M. (deposition date: 2011-01-20, release date: 2011-07-06, Last modification date: 2023-09-13) |
Primary citation | Borbulevych, O.Y.,Santhanagopolan, S.M.,Hossain, M.,Baker, B.M. TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms. J.Immunol., 187:2453-2463, 2011 Cited by PubMed: 21795600DOI: 10.4049/jimmunol.1101268 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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