3QDM

The complex between TCR DMF4 and human Class I MHC HLA-A2 with the bound MART-1(26-35)(A27L) decameric peptide

Summary for 3QDM

Entry DOI	10.2210/pdb3qdm/pdb
Related	3QDG 3QDJ 3QEQ 3QEU
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, MART-1(27-35) peptide, ... (6 entities in total)
Functional Keywords	mart-1 peptide, nonapeptide, mhc class i, hla-a2, tcr dmf5, tcr dmf4, cross-reactivity, cancer, melanoma, immune system
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769
Total number of polymer chains	5
Total formula weight	93549.71
Authors	Borbulevych, O.Y.,Baker, B.M. (deposition date: 2011-01-18, release date: 2011-07-06, Last modification date: 2023-09-13)
Primary citation	Borbulevych, O.Y.,Santhanagopolan, S.M.,Hossain, M.,Baker, B.M. TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms. J.Immunol., 187:2453-2463, 2011 Cited by PubMed: 21795600 DOI: 10.4049/jimmunol.1101268 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation