3HIO
Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue
Summary for 3HIO
Entry DOI | 10.2210/pdb3hio/pdb |
Related | 3HIQ 3HIS 3HIT 3HIV 3HIW |
Descriptor | Ricin, 9,9'-{(2R,3R,3aR,5S,7aR,9R,10R,10aR,12S,23R,25aR,27R,28R,28aR,30S,32aR,35aR,37S,39aR)-9-(6-amino-9H-purin-9-yl)-34-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5,12,23,30,37-pentahydroxy-3,10,28-trimethoxy-5,12,23,30,37-pentaoxidotetracosahydro-2H,7H,25H-trifuro[3,2-f:3',2'-l:3'',2''-x]pyrrolo[3,4-r][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]undecaoxazapentaphosphacyclopentatriacontine-2,27-diyl}bis(2-amino-3,9-dihydro-6H-purin-6-one), SULFATE ION, ... (4 entities in total) |
Functional Keywords | rta, transition state, ribosome inactivating proteins, rips, disulfide bond, glycoprotein, hydrolase, lectin, nucleotide-binding, plant defense, protein synthesis inhibitor, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Ricinus communis (Castor bean) |
Total number of polymer chains | 1 |
Total formula weight | 31762.13 |
Authors | Ho, M.,Sturm, M.B.,Goldman, J.D.,Almo, S.C.,Schramm, V.L. (deposition date: 2009-05-20, release date: 2009-12-08, Last modification date: 2024-02-21) |
Primary citation | Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106:20276-20281, 2009 Cited by PubMed: 19920175DOI: 10.1073/pnas.0911606106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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