3HIT

Crystal structure of Saporin-L1 in complex with the dinucleotide inhibitor, a transition state analogue

Summary for 3HIT

Entry DOI	10.2210/pdb3hit/pdb
Related	3HIO 3HIQ 3HIS 3HIV 3HIW
Descriptor	Vacuolar saporin, 5'-O-[(S)-{[(3R,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[(S)-hydroxy(3-hydroxypropoxy)phosphoryl]oxy}methyl)pyrrolidin-3-yl]oxy}(hydroxy)phosphoryl]-3'-O-[(R)-hydroxy(4-hydroxybutoxy)phosphoryl]-2'-O-methylguanosine (3 entities in total)
Functional Keywords	transition state, ribosome inactivating proteins, rips, hydrolase, plant defense, protein synthesis inhibitor, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Saponaria officinalis (Common soapwort)
Total number of polymer chains	2
Total formula weight	59360.89
Authors	Ho, M.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2009-05-20, release date: 2009-12-08, Last modification date: 2024-02-21)
Primary citation	Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106:20276-20281, 2009 Cited by PubMed: 19920175 DOI: 10.1073/pnas.0911606106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation