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3HIT

Crystal structure of Saporin-L1 in complex with the dinucleotide inhibitor, a transition state analogue

Functional Information from GO Data
ChainGOidnamespacecontents
A0006952biological_processdefense response
A0016787molecular_functionhydrolase activity
A0017148biological_processnegative regulation of translation
A0030598molecular_functionrRNA N-glycosylase activity
A0035821biological_processmodulation of process of another organism
A0090729molecular_functiontoxin activity
B0006952biological_processdefense response
B0016787molecular_functionhydrolase activity
B0017148biological_processnegative regulation of translation
B0030598molecular_functionrRNA N-glycosylase activity
B0035821biological_processmodulation of process of another organism
B0090729molecular_functiontoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE DYN A 258
ChainResidue
AASN71
AGLU206
AASN207
ATRP209
AGLY210
AARG214
ATYR233
ALEU254
AHOH334
AHOH336
AHOH374
ALEU72
AHOH429
ATYR73
AVAL74
AGLU121
ATYR123
AVAL169
AGLU174
AARG177

site_idAC2
Number of Residues22
DetailsBINDING SITE FOR RESIDUE DYN B 258
ChainResidue
BASN71
BLEU72
BTYR73
BVAL74
BPHE94
BGLU121
BSER122
BTYR123
BGLU174
BARG177
BGLU206
BASN207
BASN208
BTRP209
BGLY210
BARG214
BTYR233
BLEU254
BHOH317
BHOH337
BHOH338
BHOH348

Functional Information from PROSITE/UniProt
site_idPS00275
Number of Residues17
DetailsSHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. VqMVgEAARFKyIEnlV
ChainResidueDetails
AVAL169-VAL185

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1abr
ChainResidueDetails
AARG177
AGLU174

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1abr
ChainResidueDetails
BARG177
BGLU174

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PDB entries from 2024-11-06

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