3QHB

Crystal structure of oxidized Symerythrin from Cyanophora paradoxa

Summary for 3QHB

Entry DOI	10.2210/pdb3qhb/pdb
Related	3QHC
Descriptor	Symerythrin, FE (III) ION (3 entities in total)
Functional Keywords	four-helix bundle, carboxylate bridged-diiron, ferritin-like superfamily, metal transport
Biological source	Cyanophora paradoxa
Cellular location	Plastid, cyanelle: P48329
Total number of polymer chains	2
Total formula weight	39987.70
Authors	Cooley, R.B.,Arp, D.J.,Karplus, P.A. (deposition date: 2011-01-25, release date: 2011-05-25, Last modification date: 2024-11-20)
Primary citation	Cooley, R.B.,Rhoads, T.W.,Arp, D.J.,Karplus, P.A. A diiron protein autogenerates a valine-phenylalanine cross-link. Science, 332:929-929, 2011 Cited by PubMed Abstract: All known internal covalent cross-links in proteins involve functionalized groups having oxygen, nitrogen, or sulfur atoms present to facilitate their formation. Here, we report a carbon-carbon cross-link between two unfunctionalized side chains. This valine-phenyalanine cross-link, produced in an oxygen-dependent reaction, is generated by its own carboxylate-bridged diiron center and serves to stabilize the metallocenter. This finding opens the door to new types of posttranslational modifications, and it demonstrates new catalytic potential of diiron centers. PubMed: 21596985 DOI: 10.1126/science.1205687 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation