PDB: 128 件ウェブページステータス検索Chemie searchBIRD

---

1D4V	Crystal structure of trail-DR5 complex 分子名称: DEATH RECEPTOR 5, TNF-RELATED APOPTOSIS INDUCING LIGAND 著者 Mongkolsapaya, J, Grimes, J.M, Stuart, D.I, Jones, E.Y, Screaton, G.R. 登録日 1999-10-06 公開日 1999-11-01 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation Nat.Struct.Biol., 6, 1999
6A3V	Complex structure of human 4-1BB and 4-1BBL 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 著者 Li, Y, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. 登録日 2018-06-17 公開日 2018-10-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.391 Å) 主引用文献 Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep, 25, 2018
3K51	Crystal Structure of DcR3-TL1A complex 分子名称: Decoy receptor 3, Tumor necrosis factor ligand superfamily member 15, secreted form 著者 Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. 登録日 2009-10-06 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011
3L9J	Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex 分子名称: MAGNESIUM ION, TNFalpha, Tumor necrosis factor, ... 著者 Byla, P, Andersen, M.H, Thogersen, H.C, Gad, H.H, Hartmann, R. 登録日 2010-01-05 公開日 2010-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex J.Biol.Chem., 285, 2010
1DU3	Crystal structure of TRAIL-SDR5 分子名称: DEATH RECEPTOR 5, TNF-RELATED APOPTOSIS INDUCING LIGAND, ZINC ION 著者 Cha, S.-S, Sung, B.-J, Oh, B.-H. 登録日 2000-01-14 公開日 2000-09-27 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificity J.Biol.Chem., 275, 2000
4E4D	Crystal structure of mouse RANKL-OPG complex 分子名称: CHLORIDE ION, Tumor necrosis factor ligand superfamily member 11, soluble form, ... 著者 Nelson, C.A, Fremont, D.H. 登録日 2012-03-12 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor. Structure, 20, 2012
4N90	Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody 分子名称: Fab heavy chain, Fab light chain, Tumor necrosis factor ligand superfamily member 10, ... 著者 Huang, X. 登録日 2013-10-18 公開日 2014-09-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity. Cancer Cell, 26, 2014
6MGP	Structure of human 4-1BB / 4-1BBL complex 分子名称: ACETATE ION, GLYCEROL, Tumor necrosis factor ligand superfamily member 9, ... 著者 Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. 登録日 2018-09-14 公開日 2018-11-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab Nat Commun, 9, 2018
6MKZ	Crystal structure of murine 4-1BB/4-1BBL complex 分子名称: Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Bitra, A, Zajonc, D.M, Doukov, T. 登録日 2018-09-26 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding. J. Biol. Chem., 294, 2019
3ME2	Crystal structure of mouse RANKL-RANK complex 分子名称: CHLORIDE ION, SODIUM ION, Tumor necrosis factor ligand superfamily member 11, ... 著者 Walter, S.W, Liu, C.Z, Zhu, X.K, Wu, Y, Owens, R.J, Stuart, D.I, Gao, B, Ren, J. 登録日 2010-03-31 公開日 2010-06-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and Functional Insights of RANKL-RANK Interaction and Signaling. J.Immunol., 2010
3MI8	The structure of TL1A-DCR3 COMPLEX 分子名称: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15, SECRETED FORM, Tumor necrosis factor receptor superfamily member 6B 著者 Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. 登録日 2010-04-09 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.951 Å) 主引用文献 Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011
4MXW	Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab 分子名称: Lymphotoxin-alpha, Lymphotoxin-beta, Tumor necrosis factor receptor superfamily member 3, ... 著者 Sudhamsu, J, Yin, J.P, Hymowitz, S.G. 登録日 2013-09-26 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
4GIQ	Crystal Structure of mouse RANK bound to RANKL 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SODIUM ION, ... 著者 Nelson, C.A, Wang, M.W.-H, Fremont, D.H. 登録日 2012-08-08 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor. Structure, 20, 2012
1D0G	CRYSTAL STRUCTURE OF DEATH RECEPTOR 5 (DR5) BOUND TO APO2L/TRAIL 分子名称: APOPTOSIS-2 LIGAND, CHLORIDE ION, DEATH RECEPTOR-5, ... 著者 Hymowitz, S.G, Christinger, H.W, Fuh, G, O'Connell, M.P, Kelley, R.F, Ashkenazi, A, de Vos, A.M. 登録日 1999-09-09 公開日 1999-10-22 最終更新日 2018-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol.Cell, 4, 1999
3ALQ	Crystal structure of TNF-TNFR2 complex 分子名称: COBALT (II) ION, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1B 著者 Mukai, Y, Nakamura, T, Yamagata, Y, Tsutsumi, Y. 登録日 2010-08-06 公開日 2010-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Solution of the Structure of the TNF-TNFR2 Complex Sci.Signal., 3, 2010
4MSV	Crystal structure of FASL and DcR3 complex 分子名称: GLYCEROL, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 6, ... 著者 Liu, W, Ramagopal, U.A, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-09-18 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure, 24, 2016
6CPR	Crystal structure of 4-1BBL/4-1BB complex in C2 space group 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... 著者 Aruna, B, Zajonc, D.M. 登録日 2018-03-14 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. J. Biol. Chem., 293, 2018
4KGG	Crystal structure of light mutant2 and dcr3 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... 著者 Liu, W, Bonanno, J.B, Zhan, C, Kumar, P.R, Toro, R, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-04-29 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
6BWV	Crystal Structure of the 4-1BB/4-1BBL Complex 分子名称: DI(HYDROXYETHYL)ETHER, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 著者 Oganesyan, V, Gilbreth, R.N, Baca, M. 登録日 2017-12-15 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the human 4-1BB/4-1BBL complex. J. Biol. Chem., 293, 2018
6BRB	Novel non-antibody protein scaffold targeting CD40L 分子名称: CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F. 登録日 2017-11-30 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11, 2019
6CU0	Crystal structure of 4-1BBL/4-1BB (C121S) complex in P21 space group 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 著者 Aruna, B, Zajonc, D.M, Doukov, T. 登録日 2018-03-23 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. J. Biol. Chem., 293, 2018
4J6G	CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ... 著者 Liu, W, Zhan, C, Bonanno, J.B, Bhosle, R.C, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-02-11 公開日 2013-03-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
4KGQ	Crystal structure of a human light loop mutant in complex with dcr3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 14, ... 著者 Liu, W, Zhan, C, Bonanno, J.B, Sampathkumar, P, Toro, R, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) 登録日 2013-04-29 公開日 2013-07-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure, 22, 2014
7KP7	asymmetric mTNF-alpha hTNFR1 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor, ... 著者 Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T. 登録日 2020-11-10 公開日 2021-01-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12, 2021
7KPB	Human TNF-alpha TNFR1 complex bound to conformationally selective antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one, Fab1974 - Heavy Chain, ... 著者 Fox III, D, Conrady, D.G, Lowe, M, Ceska, T. 登録日 2020-11-10 公開日 2021-01-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF Nat Commun, 12, 2021

<123456>