3L9J
Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex
Summary for 3L9J
Entry DOI | 10.2210/pdb3l9j/pdb |
Descriptor | TNFalpha, Tumor necrosis factor, soluble form, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | tnf-alpha, antagonist, in vitro selection, cell membrane, cytokine, disulfide bond, glycoprotein, lipoprotein, secreted, signal-anchor, transmembrane, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375 |
Total number of polymer chains | 2 |
Total formula weight | 31836.15 |
Authors | Byla, P.,Andersen, M.H.,Thogersen, H.C.,Gad, H.H.,Hartmann, R. (deposition date: 2010-01-05, release date: 2010-02-23, Last modification date: 2023-11-01) |
Primary citation | Byla, P.,Andersen, M.H.,Holtet, T.L.,Jacobsen, H.,Munch, M.,Gad, H.H.,Thogersen, H.C.,Hartmann, R. Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex J.Biol.Chem., 285:12096-12100, 2010 Cited by PubMed: 20179326DOI: 10.1074/jbc.M109.063305 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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