3ZK4
 
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7BBJ
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4V0W
 | | The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-669) | | 分子名称: | MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT | | 著者 | Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. | | 登録日 | 2014-09-18 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases.
Elife, 4, 2015
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5B8I
 | | Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, ... | | 著者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fox III, D, Dranow, D.M, Lorimer, D.D, Edwards, T.E. | | 登録日 | 2015-05-03 | | 公開日 | 2015-05-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
Nat Commun, 10, 2019
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7CUN
 | | The structure of human Integrator-PP2A complex | | 分子名称: | Integrator complex subunit 1, Integrator complex subunit 11, Integrator complex subunit 2, ... | | 著者 | Zheng, H, Qi, Y, Liu, W, Li, J, Wang, J, Xu, Y. | | 登録日 | 2020-08-23 | | 公開日 | 2020-11-25 | | 最終更新日 | 2020-12-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Science, 370, 2020
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4WWL
 | | E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form) | | 分子名称: | CARBONATE ION, GLYCEROL, Protein UshA, ... | | 著者 | Krug, U, Paithankar, K.S, Schultz-Heienbrok, R, Strater, N. | | 登録日 | 2014-11-11 | | 公開日 | 2014-11-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form)
To Be Published
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5ZT0
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7D0V
 | | Crystal structure of Taiwan cobra 5'-nucleotidase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Snake venom 5'-nucleotidase, ... | | 著者 | Tsai, M.-H, Lin, I.-J, Lin, C.-C, Wu, W.-G. | | 登録日 | 2020-09-12 | | 公開日 | 2021-09-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | | 主引用文献 | Crystal structure of Taiwan cobra 5'-nucleotidase
To Be Published
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1WAO
 | | PP5 structure | | 分子名称: | MANGANESE (II) ION, SERINE/THREONINE PROTEIN PHOSPHATASE 5 | | 著者 | Barford, D. | | 登録日 | 2004-10-27 | | 公開日 | 2005-02-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Molecular Basis for Tpr Domain-Mediated Regulation of Protein Phosphatase 5
Embo J., 24, 2005
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6ASC
 | | Mre11 dimer in complex with Endonuclease inhibitor PFM04 | | 分子名称: | (5E)-3-butyl-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 1,2-ETHANEDIOL, MANGANESE (II) ION, ... | | 著者 | Moiani, D, Arvai, A.S, Tainer, J.A. | | 登録日 | 2017-08-24 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.
Meth. Enzymol., 601, 2018
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7DOG
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3ZTV
 | | Structure of Haemophilus influenzae NAD nucleotidase (NadN) | | 分子名称: | ADENOSINE, GLYCEROL, NAD NUCLEOTIDASE, ... | | 著者 | Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M. | | 登録日 | 2011-07-12 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012
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3ZU0
 | | Structure of Haemophilus influenzae NAD nucleotidase (NadN) | | 分子名称: | NAD NUCLEOTIDASE, PHOSPHATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | | 著者 | Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M. | | 登録日 | 2011-07-13 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | | 主引用文献 | The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012
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5ZQV
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7YZP
 | | Hairpin-bound state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and a DNA hairpin | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA hairpin (59-MER), MAGNESIUM ION, ... | | 著者 | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | 登録日 | 2022-02-21 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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7Z03
 | | Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and extended dsDNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (39-MER), MAGNESIUM ION, ... | | 著者 | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | 登録日 | 2022-02-21 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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7YZO
 | | Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), MAGNESIUM ION, ... | | 著者 | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | 登録日 | 2022-02-21 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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6ALZ
 | | Crystal structure of Protein Phosphatase 1 bound to the natural inhibitor Tautomycetin | | 分子名称: | (2Z)-2-[(1R)-3-{[(2R,3S,4R,7S,8S,11S,13R,16E)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Choy, M.S, Peti, W, Page, R. | | 登録日 | 2017-08-08 | | 公開日 | 2017-11-29 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.208 Å) | | 主引用文献 | PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.
J. Am. Chem. Soc., 139, 2017
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1XZW
 | | Sweet potato purple acid phosphatase/phosphate complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ... | | 著者 | Schenk, G, Carrington, L.E, Gahan, L.R, Hamilton, S.E, de Jersey, J, Guddat, L.W. | | 登録日 | 2004-11-12 | | 公開日 | 2004-12-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase
Proc.Natl.Acad.Sci.USA, 102, 2005
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3KBP
 | | KIDNEY BEAN PURPLE ACID PHOSPHATASE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PURPLE ACID PHOSPHATASE, ... | | 著者 | Klabunde, T, Strater, N, Krebs, B. | | 登録日 | 1995-10-02 | | 公開日 | 1996-12-07 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures.
J.Mol.Biol., 259, 1996
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2QFP
 | | Crystal structure of red kidney bean purple acid phosphatase in complex with fluoride | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, FLUORIDE ION, ... | | 著者 | Guddat, L.W, Schenk, G.S, Gahan, L.R, Elliot, T.W, Leung, E. | | 登録日 | 2007-06-27 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle.
Bmc Struct.Biol., 8, 2008
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1M63
 | | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes | | 分子名称: | CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CYCLOSPORIN A, ... | | 著者 | Huai, Q, Kim, H.-Y, Liu, Y, Zhao, Y, Mondragon, A, Liu, J.O, Ke, H. | | 登録日 | 2002-07-12 | | 公開日 | 2002-09-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
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3LL8
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2USH
 | | 5'-NUCLEOTIDASE FROM E. COLI | | 分子名称: | 5'-NUCLEOTIDASE, TUNGSTATE(VI)ION, ZINC ION | | 著者 | Knofel, T, Strater, N. | | 登録日 | 1998-09-24 | | 公開日 | 1999-06-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site.
Nat.Struct.Biol., 6, 1999
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3T1I
 | | Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Double-strand break repair protein MRE11A, GLYCEROL, ... | | 著者 | Park, Y.B, Chae, J, Kim, Y, Cho, Y. | | 登録日 | 2011-07-22 | | 公開日 | 2011-11-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of human mre11: understanding tumorigenic mutations
Structure, 19, 2011
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