6ASC

Mre11 dimer in complex with Endonuclease inhibitor PFM04

Summary for 6ASC

Entry DOI	10.2210/pdb6asc/pdb
Descriptor	Nuclease SbcCD subunit D, MANGANESE (II) ION, (5E)-3-butyl-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, ... (5 entities in total)
Functional Keywords	dna repair mre11 thermophilic nuclease dna double-strand break repair hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Thermotoga maritima
Total number of polymer chains	2
Total formula weight	78019.06
Authors	Moiani, D.,Arvai, A.S.,Tainer, J.A. (deposition date: 2017-08-24, release date: 2018-03-07, Last modification date: 2024-03-13)
Primary citation	Moiani, D.,Ronato, D.A.,Brosey, C.A.,Arvai, A.S.,Syed, A.,Masson, J.Y.,Petricci, E.,Tainer, J.A. Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Meth. Enzymol., 601:205-241, 2018 Cited by PubMed: 29523233 DOI: 10.1016/bs.mie.2017.11.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation