6ASC

Mre11 dimer in complex with Endonuclease inhibitor PFM04

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nuclease SbcCD subunit D	polymer	336	38575.2	2	UniProt (Q9X1X0) Pfam (PF00149) Pfam (PF22155)	Thermotoga maritima
2	C, D, F, G (A, B)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3	E, H (A, B)	(5E)-3-butyl-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one	non-polymer		293.4	2	Chemie (BU7)
4	I (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	J, K (A, B)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

A, B: 2 - 324 (UniProt: Q9X1X0)

PDB	External Database	Details
Met -11	-	initiating methionine
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Val 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77150.4
Non-Polymers*	Number of molecules	7
	Total formula weight	868.6
All*	Total formula weight	78019.1

*Water molecules are not included.