5B8I

Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS

Summary for 5B8I

• Entry DOI: 10.2210/pdb5b8i/pdb
• Descriptor: Serine/threonine-protein phosphatase, Calcineurin subunit B, variant, Peptidylprolyl isomerase, ... (10 entities in total)
• Functional Keywords: ssgcid, nih, niaid, sbri, uw, beryllium, phosphatase, calcineurin, fkbp12, fk506, structural genomics, seattle structural genomics center for infectious disease, hydrolase
• Biological source: Coccidioides immitis (strain RS) (Valley fever fungus); More
• Total number of polymer chains: 3
• Total formula weight: 81217.37

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID),Fox III, D.,Dranow, D.M.,Lorimer, D.D.,Edwards, T.E. (deposition date: 2015-05-03, release date: 2015-05-20, Last modification date: 2023-09-27)

• Primary citation: Juvvadi, P.R.,Fox 3rd, D.,Bobay, B.G.,Hoy, M.J.,Gobeil, S.M.C.,Venters, R.A.,Chang, Z.,Lin, J.J.,Averette, A.F.,Cole, D.C.,Barrington, B.C.,Wheaton, J.D.,Ciofani, M.,Trzoss, M.,Li, X.,Lee, S.C.,Chen, Y.L.,Mutz, M.,Spicer, L.D.,Schumacher, M.A.,Heitman, J.,Steinbach, W.J.; Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.; Nat Commun, 10:4275-4275, 2019; PubMed: 31537789; DOI: 10.1038/s41467-019-12199-1

Experimental method

X-RAY DIFFRACTION (1.85 Å)