5B8I
Crystal structure of Calcineurin A and Calcineurin B in complex with FKBP12 and FK506 from Coccidioides immitis RS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein phosphatase | polymer | 390 | 45097.1 | 1 | UniProt (J3K9C5) Pfam (PF00149) UniProt (by SIFTS) (J3K8M7) | Coccidioides immitis (strain RS) (Valley fever fungus) | |
| 2 | B (B) | Calcineurin subunit B, variant | polymer | 171 | 19502.9 | 1 | UniProt (A0A0D8JSK0) Pfam (PF13499) | Coccidioides immitis (strain RS) (Valley fever fungus) | |
| 3 | C (C) | Peptidylprolyl isomerase | polymer | 130 | 14458.5 | 1 | UniProt (J3K5Z5) Pfam (PF00254) | Coccidioides immitis (strain RS) (Valley fever fungus) | |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 6 | F, G (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 7 | H, I, J, K, L... (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 8 | N, O, P, Q (B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 9 | T (C) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 1 | Chemie (FK5) | |||
| 10 | X, Y, Z (A, B, C) | water | water | 18.0 | 687 | Chemie (HOH) |
Sequence modifications
A: 22 - 390 (UniProt: J3K9C5)
B: 2 - 171 (UniProt: A0A0D8JSK0)
C: 11 - 129 (UniProt: J3K5Z5)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Ser 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| Ser 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Glu 14 | - | expression tag |
| Asn 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Tyr 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Ser 21 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Trp 1 | - | expression tag |
| Ser 2 | - | expression tag |
| His 3 | - | expression tag |
| Pro 4 | - | expression tag |
| Gln 5 | - | expression tag |
| Phe 6 | - | expression tag |
| Glu 7 | - | expression tag |
| Lys 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Ser 10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 79058.6 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2158.8 | |
| All* | Total formula weight | 81217.4 |
