6ALZ
Crystal structure of Protein Phosphatase 1 bound to the natural inhibitor Tautomycetin
Summary for 6ALZ
Entry DOI | 10.2210/pdb6alz/pdb |
Descriptor | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, MANGANESE (II) ION, (2Z)-2-[(1R)-3-{[(2R,3S,4R,7S,8S,11S,13R,16E)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70013.51 |
Authors | Choy, M.S.,Peti, W.,Page, R. (deposition date: 2017-08-08, release date: 2017-11-29, Last modification date: 2023-10-04) |
Primary citation | Choy, M.S.,Swingle, M.,D'Arcy, B.,Abney, K.,Rusin, S.F.,Kettenbach, A.N.,Page, R.,Honkanen, R.E.,Peti, W. PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. J. Am. Chem. Soc., 139:17703-17706, 2017 Cited by PubMed: 29156132DOI: 10.1021/jacs.7b09368 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.208 Å) |
Structure validation
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