PDB: 468 件ウェブページステータス検索Chemie searchBIRD

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1R6A	Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate 分子名称: Genome polyprotein, RIBAVIRIN MONOPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Benarroch, D, Egloff, M.P, Mulard, L, Romette, J.L, Canard, B. 登録日 2003-10-15 公開日 2004-09-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate. J.Biol.Chem., 279, 2004
5EIF	DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB2C3 分子名称: 2-azanyl-4-methyl-benzoic acid, Genome polyprotein, S-ADENOSYLMETHIONINE 著者 Barral, K, Bricogne, G, Sharff, A. 登録日 2015-10-29 公開日 2016-10-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
5EHG	DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF341 分子名称: 4-[3-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]phenyl]sulfonyloxybenzoic acid, RNA-directed RNA polymerase NS5, S-ADENOSYLMETHIONINE 著者 Barral, K, Bricogne, G, Sharff, A. 登録日 2015-10-28 公開日 2016-10-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
5EKX	DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYLMETHIONINE AND FRAGMENT NB2E11 分子名称: 4-chloro-5-methylbenzene-1,2-diamine, NS5 METHYLTRANSFERASE, S-ADENOSYLMETHIONINE 著者 Barral, K, Bricogne, G, Sharff, A. 登録日 2015-11-04 公開日 2016-10-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
5EIW	DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB3C2 分子名称: 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, NS5 methyltransferase, S-ADENOSYLMETHIONINE 著者 Barral, K, Bricogne, G, Sharff, A. 登録日 2015-10-30 公開日 2016-10-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.611 Å) 主引用文献 Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
2WZQ	Insertion Mutant E173GP174 of the NS3 protease-helicase from dengue virus 分子名称: CHLORIDE ION, GLYCEROL, NS3 PROTEASE-HELICASE 著者 Luo, D, Wei, N, Doan, D, Paradkar, P, Chong, Y, Davidson, A, Kotaka, M, Lescar, J, Vasudevan, S. 登録日 2009-12-02 公開日 2010-04-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Flexibility between the Protease and Helicase Domains of the Dengue Virus Ns3 Protein Conferred by the Linker Region and its Functional Implications. J.Biol.Chem., 285, 2010
5E9Q	DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF174 分子名称: 2-({[2-amino-4-(trifluoromethyl)phenyl]carbamoyl}amino)-4-methylbenzoic acid, Genome polyprotein, S-ADENOSYLMETHIONINE 著者 Barral, K, Bricogne, G, Sharff, A. 登録日 2015-10-15 公開日 2016-10-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
5N09	Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 - Heavy chain, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 - Light chain, ... 著者 Duquerroy, S, Rouvinski, A, Guardado-Calvo, P, Vaney, M.-C, Sharma, A, Rey, F. 登録日 2017-02-02 公開日 2017-06-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope. Nat Commun, 8, 2017
5N0A	Crystal structure of A259C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 分子名称: BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 HEAVY CHAIN, Envelope Glycoprotein E, ... 著者 Vaney, M.C, Rouvinski, A, Guardado-Calvo, P, Sharma, A, Rey, F.A. 登録日 2017-02-02 公開日 2017-06-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope. Nat Commun, 8, 2017
8VPU	Crystal structure of mouse Importin alpha in complex with dengue virus 3 NS5 central NLS peptide 分子名称: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 central NLS peptide 著者 Roman, N, Swarbrick, C.M.D, Forwood, J.K. 登録日 2024-01-17 公開日 2024-08-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization. Acs Infect Dis., 10, 2024
2P3L	Crystal Structure of Dengue Methyltransferase in Complex with GpppA and S-Adenosyl-L-Homocysteine 分子名称: CITRIC ACID, GLYCEROL, GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ... 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-09 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
2P3O	Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppA and S-Adenosyl-L-homocysteine 分子名称: CITRIC ACID, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-09 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.756 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
2P40	Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, SULFATE ION, type II methyltransferase 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-11 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
2P41	Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE, CITRIC ACID, GLYCEROL, ... 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-11 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
2P3Q	Crystal Structure of Dengue Methyltransferase in Complex with GpppG and S-Adenosyl-L-homocysteine 分子名称: DIGUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-09 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
8VPR	Crystal structure of mouse Importin alpha in complex with Dengue 1 NS5 central NLS peptide 分子名称: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 central NLS peptide 著者 Cheng, C.X, Swarbrick, C.M.D, Forward, J.K. 登録日 2024-01-16 公開日 2024-08-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization. Acs Infect Dis., 10, 2024
3VTT	High Resolution crystal structure of Dengue 3 Envelope protein domain III (ED3) 分子名称: Envelope protein E, SULFATE ION 著者 Elahi, M, Islam, M.M, Kuroda, Y. 登録日 2012-06-07 公開日 2012-12-26 最終更新日 2013-08-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 High resolution crystal structure of dengue-3 envelope protein domain III suggests possible molecular mechanisms for serospecific antibody recognition Proteins, 81, 2013
7CTH	Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Core protein, Single Chain Variable Fragment 著者 Zhang, X, Sharma, A, Duquerroy, S, Zhou, Z.H, Rey, F.A. 登録日 2020-08-19 公開日 2021-12-01 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
3J42	Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody 分子名称: Envelope protein E, Ig heavy chain V region MOPC 21, Igh protein chimera, ... 著者 Wang, Z, Pennington, J.G, Jiang, W, Rossmann, M.G. 登録日 2013-06-13 公開日 2013-07-17 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (21 Å) 主引用文献 Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody. J.Virol., 87, 2013
3ZKO	The structure of ''breathing'' dengue virus. 分子名称: ENVELOPE GLYCOPROTEIN 著者 Fibriansah, G, Ng, T.S, Kostyuchenko, V.A, Lee, S, Wang, J, Lok, S.M. 登録日 2013-01-24 公開日 2013-05-15 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (13.7 Å) 主引用文献 Structural Changes of Dengue Virus When Exposed to 37 Degrees C. J.Virol., 87, 2013
3U1J	Aprotinin bound to Dengue virus protease 分子名称: Pancreatic trypsin inhibitor, Serine protease NS3, Serine protease subunit NS2B 著者 Noble, C.G. 登録日 2011-09-30 公開日 2011-11-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Ligand-bound structures of the dengue virus protease reveal the active conformation J.Virol., 86, 2012
3UAJ	Crystal structure of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, monoclonal antibody 5H2, ... 著者 Cockburn, J.J.B, Stura, E.A, Navarro-Sanchez, M.E, Rey, F.A. 登録日 2011-10-21 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.232 Å) 主引用文献 Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus. Embo J., 31, 2012
3UC0	Crystal structure of domain I of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2 分子名称: GLYCEROL, Heavy chain, monoclonal antibody 5H2, ... 著者 Cockburn, J.J.B, Stura, E.A, Navarro-Sanchez, M.E, Rey, F.A. 登録日 2011-10-25 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus. Embo J., 31, 2012
3WE1	Crystal structure of Dengue 4 Envelope protein domain III (ED3) 分子名称: Envelope protein E 著者 Elahi, M, Islam, M.M, Noguchi, K, Yohda, M, Toh, H, Kuroda, Y. 登録日 2013-06-27 公開日 2014-01-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.278 Å) 主引用文献 Computational prediction and experimental characterization of a "size switch type repacking" during the evolution of dengue envelope protein domain III (ED3). Biochim.Biophys.Acta, 1844, 2014
3IYA	Association of the pr peptides with dengue virus blocks membrane fusion at acidic pH 分子名称: Envelope protein, prM protein 著者 Yu, I, Holdaway, H.A, Chipman, P.R, Kuhn, R.J, Rossmann, M.G, Chen, J. 登録日 2009-06-01 公開日 2010-04-14 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (22 Å) 主引用文献 Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion. J.Virol., 83, 2009

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