2P3L

Crystal Structure of Dengue Methyltransferase in Complex with GpppA and S-Adenosyl-L-Homocysteine

Summary for 2P3L

• Entry DOI: 10.2210/pdb2p3l/pdb
• Related: 1L9K 2P1D 2P3O 2P3Q 2P40 2P41
• Descriptor: type II methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (7 entities in total)
• Functional Keywords: vizier; viral enzymes involved in replication; dengue virus methyltransferase; structural genomics; marseilles structural genomics program @ afmb; msgp, viral protein, transferase
• Biological source: Dengue virus 2
• Cellular location: Envelope protein E: Virion membrane; Multi- pass membrane protein: Q9WLZ8
• Total number of polymer chains: 1
• Total formula weight: 36318.38

Authors

Egloff, M.P.,Marseilles Structural Genomics Program @ AFMB (MSGP) (deposition date: 2007-03-09, release date: 2007-08-28, Last modification date: 2023-08-30)

• Primary citation: Egloff, M.P.,Decroly, E.,Malet, H.,Selisko, B.,Benarroch, D.,Ferron, F.,Canard, B.; Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5; J.Mol.Biol., 372:723-736, 2007; PubMed: 17686489; DOI: 10.1016/j.jmb.2007.07.005

Experimental method

X-RAY DIFFRACTION (2.2 Å)