2P3L

Crystal Structure of Dengue Methyltransferase in Complex with GpppA and S-Adenosyl-L-Homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	LYS29
A	ARG57
A	ARG212
A	THR215
A	HOH1022
A	HOH1069
A	HOH1070

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	ARG57
A	ARG84
A	HOH1040
A	HOH1041
A	ARG38
A	SER56

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1007

Chain	Residue
A	LYS105
A	HIS110
A	SER150
A	SER151
A	ARG160
A	HOH1049

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1008

Chain	Residue
A	PRO108
A	GLY109

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1009

Chain	Residue
A	GLY109
A	HIS110
A	GLU111
A	SAH1001

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH A 1001

Chain	Residue
A	SER56
A	GLY58
A	GLY81
A	CYS82
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	HIS110
A	VAL130
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	CIT1003
A	SO41009
A	HOH1026
A	HOH1028
A	HOH1046
A	HOH1076

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE G3A A 1002

Chain	Residue
A	LYS14
A	LEU17
A	ASN18
A	LEU20
A	PHE25
A	LYS29
A	PRO108
A	SER150
A	SER151
A	PRO152
A	SER214
A	HOH1051
A	HOH1060
A	HOH1070
A	HOH1075
A	HOH1080

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT A 1003

Chain	Residue
A	LYS105
A	ASP131
A	PHE134
A	GLY159
A	ARG160
A	ARG163
A	SAH1001
A	HOH1052
A	HOH1076

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1004

Chain	Residue
A	LYS30
A	ARG212

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