2P3L
Crystal Structure of Dengue Methyltransferase in Complex with GpppA and S-Adenosyl-L-Homocysteine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | type II methyltransferase | polymer | 305 | 34397.0 | 1 | UniProt (Q9WLZ8) Pfam (PF01728) UniProt (by SIFTS) (Q9WLZ5) | Dengue virus 2 | |
| 2 | B, C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | G (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | H (A) | GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | non-polymer | 772.4 | 1 | Chemie (G3A) | |||
| 5 | I (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 6 | J (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | K (A) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 4 - 296 (UniProt: Q9WLZ8)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | expression tag |
| Arg -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 70 | Met 2561 | SEE REMARK 999 |
| Arg 139 | Lys 2630 | SEE REMARK 999 |
| Ser 173 | Asn 2664 | SEE REMARK 999 |
| Val 180 | Ile 2671 | SEE REMARK 999 |
| Ser 188 | Pro 2679 | SEE REMARK 999 |
| His 201 | Tyr 2692 | SEE REMARK 999 |
| Thr 271 | Ile 2762 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34397.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1921.4 | |
| All* | Total formula weight | 36318.4 |
