7CTH

Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10

Summary for 7CTH

Entry DOI	10.2210/pdb7cth/pdb
EMDB information	30465
Descriptor	Core protein, Single Chain Variable Fragment, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	dengue virus, antibody, broadly neutralizing, flavivirus, virus
Biological source	Dengue virus 2 More
Total number of polymer chains	10
Total formula weight	251601.36
Authors	Zhang, X.,Sharma, A.,Duquerroy, S.,Zhou, Z.H.,Rey, F.A. (deposition date: 2020-08-19, release date: 2021-12-01, Last modification date: 2022-02-16)
Primary citation	Sharma, A.,Zhang, X.,Dejnirattisai, W.,Dai, X.,Gong, D.,Wongwiwat, W.,Duquerroy, S.,Rouvinski, A.,Vaney, M.C.,Guardado-Calvo, P.,Haouz, A.,England, P.,Sun, R.,Zhou, Z.H.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A. The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184:6052-, 2021 Cited by PubMed: 34852239 DOI: 10.1016/j.cell.2021.11.010 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation