7CTH

Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Core protein	polymer	495	54351.7	3	UniProt (Q88636) Pfam (PF00869) Pfam (PF02832) Pfam (PF21659) UniProt (by SIFTS) (P14340)	Dengue virus 2	Envelope protein E,Matrix protein,Peptide pr,Protein prM,Small envelope protein M
2	D, E, F (F, D, E)	Core protein	polymer	75	8345.8	3	UniProt (Q20II5) Pfam (PF01004) UniProt (by SIFTS) (P14340)	Dengue virus 2	Envelope protein E,Flavivirin protease NS2B regulatory subunit,Flavivirin protease NS3 catalytic subunit,Genome polyprotein,Matrix protein,Non-structural protein 1,Non-structural protein 2A,Non-structural protein 2B,Non-structural protein 3,Non-structural protein 4A,Non-structural protein 4B,Peptide 2k,Peptide pr,Protein prM,RNA-directed RNA polymerase NS5,Serine protease NS3,Serine protease subunit NS2B,Small envelope protein M
3	G, I (I, H)	Single Chain Variable Fragment	polymer	144	15679.2	2		Homo sapiens
4	H, J (M, L)	Single Chain Variable Fragment	polymer	154	15632.8	2		Homo sapiens
5	K, L, M, N (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	250716.5
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	251601.4

*Water molecules are not included.