3UC0

Crystal structure of domain I of the envelope glycoprotein ectodomain from dengue virus serotype 4 in complex with the fab fragment of the chimpanzee monoclonal antibody 5H2

Summary for 3UC0

• Entry DOI: 10.2210/pdb3uc0/pdb
• Related: 3UAJ
• Descriptor: envelope protein, Heavy chain, monoclonal antibody 5H2, Light chain, monoclonal antibody 5H2, ... (6 entities in total)
• Functional Keywords: dengue antibody membrane fusion, viral protein-immune system complex, viral protein/immune system
• Biological source: Dengue virus 4; More
• Cellular location: Virion membrane ; Multi-pass membrane protein : Q91AI1
• Total number of polymer chains: 6
• Total formula weight: 133365.88

Authors

Cockburn, J.J.B.,Stura, E.A.,Navarro-Sanchez, M.E.,Rey, F.A. (deposition date: 2011-10-25, release date: 2011-12-14, Last modification date: 2023-09-13)

• Primary citation: Cockburn, J.J.,Navarro Sanchez, M.E.,Goncalvez, A.P.,Zaitseva, E.,Stura, E.A.,Kikuti, C.M.,Duquerroy, S.,Dussart, P.,Chernomordik, L.V.,Lai, C.J.,Rey, F.A.; Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus.; Embo J., 31:767-779, 2012; PubMed: 22139356; DOI: 10.1038/emboj.2011.439

Experimental method

X-RAY DIFFRACTION (2.71 Å)