PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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2C40	CRYSTAL STRUCTURE OF INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE FROM BACILLUS ANTHRACIS AT 2.2A RESOLUTION 分子名称: CALCIUM ION, INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE FAMILY PROTEIN, alpha-D-ribofuranose 著者 Moroz, O.V, Blagova, E.V, Fogg, M.J, Levdikov, V.M, Brannigan, J.A, Wilkinson, A.J, Wilson, K.S. 登録日 2005-10-13 公開日 2007-02-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of Inosine-Uridine Preferring Nucleoside Hydrolase from Bacillus Anthracis at 2.2A Resolution To be Published
5FYD	Structural and biochemical insights into 7beta-hydroxysteroid dehydrogenase stereoselectivity 分子名称: GLYCEROL, OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY PROTEIN 著者 Savino, S, Ferrandi, E, Forneris, F, Rovida, S, Riva, S, Monti, D, Mattevi, A. 登録日 2016-03-07 公開日 2016-04-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and Biochemical Insights Into 7Beta-Hydroxysteroid Dehydrogenase Stereoselectivity. Proteins, 84, 2016
5GVQ	Solution structure of the first RRM domain of human spliceosomal protein SF3b49 分子名称: Splicing factor 3B subunit 4 著者 Kuwasako, K, Nameki, N, Tsuda, K, Takahashi, M, Sato, A, Tochio, N, Inoue, M, Terada, T, Kigawa, T, Kobayashi, N, Shirouzu, M, Ito, T, Sakamoto, T, Wakamatsu, K, Guntert, P, Takahashi, S, Yokoyama, S, Muto, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2016-09-06 公開日 2017-04-12 最終更新日 2025-03-19 実験手法 SOLUTION NMR 主引用文献 Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment. Protein Sci., 26, 2017
4KUD	Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast nucleosome core particle 分子名称: Histone H2A.2, Histone H2B.1, Histone H3, ... 著者 Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M. 登録日 2013-05-22 公開日 2013-08-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol., 20, 2013
7LPK	Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-2-methyl-5-[[(3~{R})-pyrrolidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-12 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7LP0	Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-077 分子名称: 1,2-ETHANEDIOL, 4-chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one, DIMETHYL SULFOXIDE, ... 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-11 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7LRK	Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-093 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-2-methyl-5-[[(3~{S})-pyrrolidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-16 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
7LRO	Crystal structure of BPTF bromodomain in complex with inhibitor HZ-01-105 分子名称: 1,2-ETHANEDIOL, 5-(azetidin-3-ylamino)-4-chloranyl-2-methyl-pyridazin-3-one, DIMETHYL SULFOXIDE, ... 著者 Chan, A, Schonbrunn, E. 登録日 2021-02-17 公開日 2022-08-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
2IW5	Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase 分子名称: AMMONIUM ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Yang, M, Gocke, C.B, Luo, X, Borek, D, Tomchick, D.R, Machius, M, Otwinowski, Z, Yu, H. 登録日 2006-06-26 公開日 2006-08-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase Mol.Cell, 23, 2006
7WLP	Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses 分子名称: Histone H2B type 1-O,Histone H2A type 1-D, Tegument protein BKRF4 著者 Chen, J, Shan, S, Zhou, Z. 登録日 2022-01-13 公開日 2022-11-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses. Proc.Natl.Acad.Sci.USA, 119, 2022
5FIU	Binding and structural studies of a 5,5-difluoromethyl adenosine nucleoside with the fluorinase enzyme 分子名称: 5'-FLUORO-5'-DEOXY-ADENOSINE SYNTHASE, 5,5-DIFLUOROMETHYL ADENOSINE, L(+)-TARTARIC ACID 著者 Thompson, S, McMahon, S.A, Naismith, J.H, O'Hagan, D. 登録日 2015-10-02 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Exploration of a Potential Difluoromethyl-Nucleoside Substrate with the Fluorinase Enzyme. Bioorg.Chem., 64, 2015
2Z83	Crystal Structure of Catalytic Domain of Japanese Encephalitis Virus NS3 Helicase/Nucleoside Triphosphatase at a Resolution 1.8 分子名称: Helicase/Nucleoside Triphosphatase 著者 Yamashita, T. 登録日 2007-08-30 公開日 2008-03-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of Catalytic Domain of Japanese Encephalitis Virus NS3 Helicase/Nucleoside Triphosphatase at a Resolution 1.8 To be Published
7SO6	Crystal Structure of HIV-1 K103N, Y181C mutant Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor 分子名称: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... 著者 Bertoletti, N, Frey, K.M, Anderson, K.S, Cisneros Trigo, J.A, Jorgensen, W.L, Chan, A.H. 登録日 2021-10-29 公開日 2022-03-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9, 2022
7SO4	Crystal Structure of HIV-1 Y181C mutant Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor 分子名称: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, Reverse transcriptase/ribonuclease H, SULFATE ION, ... 著者 Bertoletti, N, Anderson, K.S, Cisneros Trigo, J.A, Jorgensen, W.L, Frey, K.M, Chan, A.H. 登録日 2021-10-29 公開日 2022-03-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9, 2022
5E5A	Crystal structure of the chromatin-tethering domain of Human cytomegalovirus IE1 protein bound to the nucleosome core particle 分子名称: C-terminal domain of Regulatory protein IE1, DNA (146-MER), Histone H2A, ... 著者 Fang, Q, Chen, P, Wang, M, Fang, J, Yang, N, Li, G, Xu, R.M. 登録日 2015-10-08 公開日 2016-02-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.809 Å) 主引用文献 Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome Elife, 5, 2016
6FTF	Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.09 A resolution 分子名称: 1,2-ETHANEDIOL, 7-cyano-7-deazainosine, Protein kinase A regulatory subunit, ... 著者 Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. 登録日 2018-02-21 公開日 2019-04-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.09151936 Å) 主引用文献 Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun, 10, 2019
2M11	Structure of perimidinone-derived synthetic nucleoside paired with guanine in DNA duplex 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(D3N)P*GP*CP*G)-3') 著者 Kowal, E.A, Lad, R, Pallan, P.S, Muffly, E, Wawrzak, Z, Egli, M, Sturla, S.J, Stone, M.P. 登録日 2012-11-09 公開日 2013-06-12 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction. Nucleic Acids Res., 41, 2013
8SPS	High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b 分子名称: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... 著者 Lian, T, Guan, R, Bai, Y. 登録日 2023-05-03 公開日 2023-06-28 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
8SPU	Structure of ESRRB nucleosome bound OCT4 at site c 分子名称: DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... 著者 Lian, T, Guan, R, Bai, Y. 登録日 2023-05-03 公開日 2023-06-28 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
4XHM	Archaeoglobus fulgidus thioredoxin 3 M60H 分子名称: Thioredoxin (Trx-3) 著者 Dey, M, Bjork, R.E, Drennan, C.L. 登録日 2015-01-05 公開日 2015-04-29 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Rheostat Re-Wired: Alternative Hypotheses for the Control of Thioredoxin Reduction Potentials. Plos One, 10
3A6N	The nucleosome containing a testis-specific histone variant, human H3T 分子名称: 146-MER DNA, CHLORIDE ION, Histone H2A type 1-B/E, ... 著者 Tachiwana, H, Kagawa, W, Osakabe, A, Koichiro, K, Shiga, T, Kimura, H, Kurumizaka, H. 登録日 2009-09-04 公開日 2010-05-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T Proc.Natl.Acad.Sci.USA, 107, 2010
5L2B	Structure of CNTnw N149S, E332A in an outward-facing state 分子名称: 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease 著者 Hirschi, M, Johnson, Z.L, Lee, S.-Y. 登録日 2016-07-31 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature, 545, 2017
5L24	Structure of CNTnw N149L in the intermediate 2 state 分子名称: 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease 著者 Hirschi, M, Johnson, Z.L, Lee, S.-Y. 登録日 2016-07-31 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature, 545, 2017
2M62	Solution Structure of a Chi/Lambda Conotoxin fron Conus araneosus 分子名称: Chi-conotoxin-like Ar1248 著者 Sarma, S.P, Ganesan, S, Gowd K, H, Padmanabhan, B. 登録日 2013-03-19 公開日 2014-04-16 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Solution Structure of Ar1248, a Chi/Lambda conotoxin from Conus araneosus To Be Published
3AFA	The human nucleosome structure 分子名称: 146-MER DNA, CHLORIDE ION, Histone H2A type 1-B/E, ... 著者 Tachiwana, H, Kagawa, W, Osakabe, A, Koichiro, K, Shiga, T, Kimura, H, Kurumizaka, H. 登録日 2010-02-24 公開日 2010-05-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T Proc.Natl.Acad.Sci.USA, 107, 2010

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