5FIU

Binding and structural studies of a 5,5-difluoromethyl adenosine nucleoside with the fluorinase enzyme

Summary for 5FIU

• Entry DOI: 10.2210/pdb5fiu/pdb
• Descriptor: 5'-FLUORO-5'-DEOXY-ADENOSINE SYNTHASE, 5,5-DIFLUOROMETHYL ADENOSINE, L(+)-TARTARIC ACID, ... (4 entities in total)
• Functional Keywords: transferase, fluorinase, difluoromethyl, isothermal titration calorimetry
• Biological source: STREPTOMYCES CATTLEYA
• Total number of polymer chains: 3
• Total formula weight: 98516.40

Authors

Thompson, S.,McMahon, S.A.,Naismith, J.H.,O'Hagan, D. (deposition date: 2015-10-02, release date: 2015-12-23, Last modification date: 2024-01-10)

• Primary citation: Thompson, S.,Mcmahon, S.A.,Naismith, J.H.,O'Hagan, D.; Exploration of a Potential Difluoromethyl-Nucleoside Substrate with the Fluorinase Enzyme.; Bioorg.Chem., 64:37-, 2015; PubMed: 26642178; DOI: 10.1016/J.BIOORG.2015.11.003

Experimental method

X-RAY DIFFRACTION (1.84 Å)