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6XHA
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Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
分子名称: CHLORIDE ION, GLYCEROL, Isoform 2B of GTPase KRas, ...
著者Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
登録日2020-06-18
公開日2021-01-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
6XGV
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Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF
分子名称: CHLORIDE ION, GLYCEROL, GTPase KRas, ...
著者Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
登録日2020-06-18
公開日2021-01-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
6XHB
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Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II)
分子名称: CHLORIDE ION, GLYCEROL, GTPase KRas, ...
著者Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
登録日2020-06-18
公開日2021-01-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun, 12, 2021
6X2M
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Crystal Structure of unliganded CRM1-Ran-RanBP1
分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M.
登録日2020-05-20
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.351 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
6X2U
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Crystal Structure of PKINES peptide bound to CRM1
分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M.
登録日2020-05-21
公開日2020-07-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Mol.Biol.Cell, 31, 2020
8EPW
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BU of 8epw by Molmil
Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF
分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K.
登録日2022-10-06
公開日2023-06-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D .
Commun Biol, 6, 2023
3QBT
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BU of 3qbt by Molmil
Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp
分子名称: Inositol polyphosphate 5-phosphatase OCRL-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Hou, X, Hagemann, N, Schoebel, S, Blankenfeldt, W, Goody, R.S, Erdmann, K.S, Itzen, A.
登録日2011-01-14
公開日2011-03-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.
Embo J., 30, 2011
6XJP
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BU of 6xjp by Molmil
Crystal Structure of KPT-185 bound to CRM1 (537-DLTVK-541 to GLCEQ)
分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-06-24
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.802 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
6XJT
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Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ)
分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-06-24
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
8F19
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BU of 8f19 by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP)
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ...
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F1E
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Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ...
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
3RYT
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BU of 3ryt by Molmil
The Plexin A1 intracellular region in complex with Rac1
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-A1, ...
著者Zhang, X, He, H.
登録日2011-05-11
公開日2012-01-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.582 Å)
主引用文献Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization.
Sci.Signal., 5, 2012
7YPZ
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BU of 7ypz by Molmil
Zafirlukast in complex with CRM1-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ...
著者Sun, Q, Lei, Y.
登録日2022-08-05
公開日2023-08-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach.
J.Med.Chem., 66, 2023
5WFO
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BU of 5wfo by Molmil
Ligand-bound Ras:SOS:Ras complex
分子名称: 6-chloranyl-~{N}-(4-fluorophenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ...
著者Sun, Q, Phan, J, Burns, M.C, Fesik, S.W.
登録日2017-07-12
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
5WFP
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BU of 5wfp by Molmil
Ligand-bound Ras:SOS:Ras complex
分子名称: 6-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ...
著者Sun, Q, Phan, J, Burns, M.C, Fesik, S.W.
登録日2017-07-12
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
5WFQ
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BU of 5wfq by Molmil
Ligand-bound Ras:SOS:Ras complex
分子名称: 7-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ...
著者Sun, Q, Phan, J, Burns, M.C, Fesik, S.W.
登録日2017-07-12
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
5WFR
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BU of 5wfr by Molmil
Ligand-bound Ras:SOS:Ras complex
分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Sun, Q, Phan, J, Burns, M.C, Fesik, S.W.
登録日2017-07-12
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548, 2018
8BNT
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BU of 8bnt by Molmil
The DH domain of ARHGEF2 bound to RhoA
分子名称: DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ...
著者Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E.
登録日2022-11-25
公開日2022-12-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The DH domain of ARHGEF2 bound to RhoA
To Be Published
8BE7
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BU of 8be7 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic3
分子名称: GTPase HRas, SOS1-HRas-peptidomimetic3, Son of sevenless homolog 1
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE6
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BU of 8be6 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic2
分子名称: GTPase HRas, SOS1-HRas-peptidomimetic2, Son of sevenless homolog 1
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.89880252 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE8
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BU of 8be8 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic4
分子名称: FORMIC ACID, GTPase HRas, SOS1-HRas-peptidomimetic4, ...
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE9
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BU of 8be9 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic5
分子名称: CHLORIDE ION, FORMIC ACID, GTPase HRas, ...
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BEA
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BU of 8bea by Molmil
Crystal structure of SOS1-HRas-peptidomimetic10
分子名称: GTPase HRas, SOS1-HRas-peptidomimetic10, Son of sevenless homolog 1
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8A4C
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BU of 8a4c by Molmil
Structure of human Rep15:Rab3B complex.
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rab15 effector protein, ...
著者Rai, A, Vetter, I.R, Goody, R.S.
登録日2022-06-10
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.
Nat Commun, 13, 2022
8A4B
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Structure of human Rep15:Rab3B_Q81L complex.
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rab15 effector protein, ...
著者Rai, A, Vetter, I.R, Goody, R.S.
登録日2022-06-10
公開日2022-08-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.
Nat Commun, 13, 2022

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