6XHA
| Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | 分子名称: | CHLORIDE ION, GLYCEROL, Isoform 2B of GTPase KRas, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6XGV
| Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | 分子名称: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6XHB
| Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II) | 分子名称: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6X2M
| Crystal Structure of unliganded CRM1-Ran-RanBP1 | 分子名称: | Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... | 著者 | Baumhardt, J.M. | 登録日 | 2020-05-20 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.351 Å) | 主引用文献 | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6X2U
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8EPW
| Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2022-10-06 | 公開日 | 2023-06-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D . Commun Biol, 6, 2023
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3QBT
| Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp | 分子名称: | Inositol polyphosphate 5-phosphatase OCRL-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Hou, X, Hagemann, N, Schoebel, S, Blankenfeldt, W, Goody, R.S, Erdmann, K.S, Itzen, A. | 登録日 | 2011-01-14 | 公開日 | 2011-03-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. Embo J., 30, 2011
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6XJP
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6XJT
| Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ) | 分子名称: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... | 著者 | Baumhardt, J.M, Chook, Y.M. | 登録日 | 2020-06-24 | 公開日 | 2021-01-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.406 Å) | 主引用文献 | Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
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8F19
| Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) | 分子名称: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ... | 著者 | Jiou, J, Chook, Y.M. | 登録日 | 2022-11-04 | 公開日 | 2023-07-26 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1E
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3RYT
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7YPZ
| Zafirlukast in complex with CRM1-Ran-RanBP1 | 分子名称: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | 著者 | Sun, Q, Lei, Y. | 登録日 | 2022-08-05 | 公開日 | 2023-08-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
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5WFO
| Ligand-bound Ras:SOS:Ras complex | 分子名称: | 6-chloranyl-~{N}-(4-fluorophenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... | 著者 | Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. | 登録日 | 2017-07-12 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
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5WFP
| Ligand-bound Ras:SOS:Ras complex | 分子名称: | 6-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... | 著者 | Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. | 登録日 | 2017-07-12 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
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5WFQ
| Ligand-bound Ras:SOS:Ras complex | 分子名称: | 7-chloranyl-~{N}-(3-chloranyl-4-fluoranyl-phenyl)-1,2,3,4-tetrahydroacridin-9-amine, GTPase HRas, MAGNESIUM ION, ... | 著者 | Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. | 登録日 | 2017-07-12 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
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5WFR
| Ligand-bound Ras:SOS:Ras complex | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Sun, Q, Phan, J, Burns, M.C, Fesik, S.W. | 登録日 | 2017-07-12 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548, 2018
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8BNT
| The DH domain of ARHGEF2 bound to RhoA | 分子名称: | DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ... | 著者 | Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E. | 登録日 | 2022-11-25 | 公開日 | 2022-12-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The DH domain of ARHGEF2 bound to RhoA To Be Published
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8BE7
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8BE6
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8BE8
| Crystal structure of SOS1-HRas-peptidomimetic4 | 分子名称: | FORMIC ACID, GTPase HRas, SOS1-HRas-peptidomimetic4, ... | 著者 | Fischer, B, Wohlkonig, A, Steyaert, J. | 登録日 | 2022-10-21 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BE9
| Crystal structure of SOS1-HRas-peptidomimetic5 | 分子名称: | CHLORIDE ION, FORMIC ACID, GTPase HRas, ... | 著者 | Fischer, B, Wohlkonig, A, Steyaert, J. | 登録日 | 2022-10-21 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BEA
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8A4C
| Structure of human Rep15:Rab3B complex. | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rab15 effector protein, ... | 著者 | Rai, A, Vetter, I.R, Goody, R.S. | 登録日 | 2022-06-10 | 公開日 | 2022-08-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. Nat Commun, 13, 2022
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8A4B
| Structure of human Rep15:Rab3B_Q81L complex. | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rab15 effector protein, ... | 著者 | Rai, A, Vetter, I.R, Goody, R.S. | 登録日 | 2022-06-10 | 公開日 | 2022-08-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. Nat Commun, 13, 2022
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