Ligand-bound Ras:SOS:Ras complex

Summary for 5WFR

DescriptorGTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsras, sos, oncoprotein, protein-protein interaction, mapk, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane. Isoform 2: Nucleus P01112
Total number of polymer chains3
Total molecular weight95295.2
Sun, Q.,Phan, J.,Burns, M.C.,Fesik, S.W. (deposition date: 2017-07-12, release date: 2018-05-23)
Primary citation
Burns, M.C.,Howes, J.E.,Sun, Q.,Little, A.J.,Camper, D.V.,Abbott, J.R.,Phan, J.,Lee, T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548:44-52, 2018
PubMed: 29444450 (PDB entries with the same primary citation)
DOI: 10.1016/j.ab.2018.01.025
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19450.1%4.1%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5wfr
no rotation
Molmil generated image of 5wfr
rotated about x axis by 90°
Molmil generated image of 5wfr
rotated about y axis by 90°