8EIS
 
 | | Cryo-EM structure of octopus sensory receptor CRT1 | | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Octopus sensory receptor | | 著者 | Kang, G, Kim, J.J, Allard, C.A.H, Valencia-Montoya, W.A, Bellono, N.W, Hibbs, R.E. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | | 主引用文献 | Sensory specializations drive octopus and squid behaviour.
Nature, 616, 2023
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8HTI
 | | Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein | | 分子名称: | Consensus Olfactory Receptor OR52c, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Choi, C.W, Bae, J, Choi, H.-J, Kim, J. | | 登録日 | 2022-12-21 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.
Nat Commun, 14, 2023
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6TD2
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8EIZ
 | | Cryo-EM structure of squid sensory receptor CRB1 | | 分子名称: | N-benzyl-2-(2,6-dimethylanilino)-N,N-diethyl-2-oxoethan-1-aminium, Squid sensory receptor CRB1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Kang, G, Kim, J.J, Allard, C.A.H, Valencia-Montoya, W.A, van Giesen, L, Kilian, P.B, Bai, X, Bellono, N.W, Hibbs, R.E. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Sensory specializations drive octopus and squid behaviour.
Nature, 616, 2023
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5XGL
 | | Co-crystal structure of Ac-AChBPP in complex with alpha-conotoxin LvIA | | 分子名称: | Alpha-conotoxin LvIA, Soluble acetylcholine receptor | | 著者 | Wang, X.Q, Xu, M.Y, Luo, S.L, Zhu, X.P. | | 登録日 | 2017-04-14 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.439 Å) | | 主引用文献 | The crystal structure of Ac-AChBP in complex with alpha-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes
Protein Cell, 8, 2017
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5Y2Q
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8GHV
 | | Cannabinoid Receptor 1-G Protein Complex | | 分子名称: | (5Z,8Z,11Z,13S,14Z)-N-[(2R)-1-hydroxypropan-2-yl]-13-methylicosa-5,8,11,14-tetraenamide, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Krishna Kumar, K, Robertson, M.J, Skiniotis, G, Kobilka, B.K. | | 登録日 | 2023-03-12 | | 公開日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis for activation of CB1 by an endocannabinoid analog.
Nat Commun, 14, 2023
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7RB7
 | | Room temperature structure of hAChE in complex with substrate analog 4K-TMA and MMB4 oxime | | 分子名称: | 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}, 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, Acetylcholinesterase | | 著者 | Kovalevsky, A, Gerlits, O, Radic, Z. | | 登録日 | 2021-07-05 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure
Curr Res Struct Biol, 3, 2021
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7RB5
 | | Room temperature structure of hAChE in complex with substrate analog 4K-TMA | | 分子名称: | 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, Acetylcholinesterase | | 著者 | Kovalevsky, A, Gerlits, O, Radic, Z. | | 登録日 | 2021-07-05 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure
Curr Res Struct Biol, 3, 2021
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7RB6
 | | Low temperature structure of hAChE in complex with substrate analog 4K-TMA | | 分子名称: | 4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, Acetylcholinesterase, GLYCEROL, ... | | 著者 | Kovalevsky, A, Gerlits, O, Radic, Z. | | 登録日 | 2021-07-05 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure
Curr Res Struct Biol, 3, 2021
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2VLW
 | | Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative. | | 分子名称: | ACETATE ION, MUSCARINIC M1-TOXIN1, SULFATE ION | | 著者 | Menez, R, Granata, V, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D, Stura, E.A. | | 登録日 | 2008-01-17 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Different Interactions between Mt7 Toxin and the Human Muscarinic M1 Receptor in its Free and N-Methylscopolamine-Occupied States.
Mol.Pharmacol., 74, 2008
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8H0P
 | | Structure of the NMB30-NMBR and Gq complex | | 分子名称: | G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Li, C, Xu, Y, Liu, H, Cai, H, Xu, H.E, Yin, W. | | 登録日 | 2022-09-30 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Molecular recognition of itch-associated neuropeptides by bombesin receptors
Cell Res., 33, 2023
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8H0Q
 | | Structure of the GRP14-27-GRPR-Gq complex | | 分子名称: | CHOLESTEROL, G-alpha q, GRP, ... | | 著者 | Li, C, Xu, Y, Liu, H, Cai, H, Xu, H.E, Yin, W. | | 登録日 | 2022-09-30 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular recognition of itch-associated neuropeptides by bombesin receptors
Cell Res., 33, 2023
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2NM1
 | | Structure of BoNT/B in complex with its protein receptor | | 分子名称: | Botulinum neurotoxin type B, Synaptotagmin-2 | | 著者 | Jin, R, Rummel, A, Binz, T, Brunger, A.T. | | 登録日 | 2006-10-20 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
Nature, 444, 2006
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7VUG
 | | Cryo-EM structure of a class A orphan GPCR in complex with Gi | | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | | 登録日 | 2021-11-02 | | 公開日 | 2021-12-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.
Cell Res., 32, 2022
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7WVY
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | | 分子名称: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVW
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | | 分子名称: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVV
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 | | 分子名称: | FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVX
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7XXH
 | | Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11 | | 分子名称: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-05-30 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023
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7VUH
 | | Cryo-EM structure of a class A orphan GPCR | | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | | 登録日 | 2021-11-02 | | 公開日 | 2021-12-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.
Cell Res., 32, 2022
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7VUJ
 | | Cryo-EM structure of a class A orphan GPCR | | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | | 登録日 | 2021-11-02 | | 公開日 | 2021-12-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.
Cell Res., 32, 2022
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7VUI
 | | Cryo-EM structure of a class A orphan GPCR | | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | | 登録日 | 2021-11-02 | | 公開日 | 2021-12-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.
Cell Res., 32, 2022
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2JUS
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8IYS
 | | TUG891-bound FFAR4 in complex with Gq | | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | He, Y, Yin, H. | | 登録日 | 2023-04-06 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity.
Cell Res., 33, 2023
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