PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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1CI5	GLYCAN-FREE MUTANT ADHESION DOMAIN OF HUMAN CD58 (LFA-3) 分子名称: PROTEIN (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3(CD58)) 著者 Sun, Z.Y.J, Dotsch, V, Kim, M, Li, J, Reinherz, E.L, Wagner, G. 登録日 1999-04-07 公開日 1999-06-22 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies. EMBO J., 18, 1999
3JPT	Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-fluoro chloro methylene triphosphate 分子名称: 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... 著者 Batra, V.K, Upton, J, Kashmerov, B, Beard, W.A, Wilson, S.H, Goodman, M.F, McKenna, C.E. 登録日 2009-09-04 公開日 2010-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues. J.Am.Chem.Soc., 132, 2010
1CN4	ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR 分子名称: PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (ERYTHROPOIETIN) 著者 Stroud, R.M, Reid, S.W. 登録日 1999-05-25 公開日 1999-08-11 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395, 1998
5IJ8	Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor 分子名称: 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... 著者 Gajiwala, K.S, Brooun, A, Deng, Y.-L, Liu, W. 登録日 2016-03-01 公開日 2016-05-04 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nat Commun, 7, 2016
4ZG6	Structural basis for inhibition of human autotaxin by four novel compounds 分子名称: 4-{(Z)-2-[6-chloro-1-(4-fluorobenzyl)-1H-indol-3-yl]-1-cyanoethenyl}benzoic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... 著者 Stein, A.J, Bain, G, Hutchinson, J.H, Evans, J.F. 登録日 2015-04-22 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding. Mol.Pharmacol., 88, 2015
5V51	Crystal Structure of MpPR-1i Soaked with Selenourea for 10 min 分子名称: PR-1 protein, selenourea 著者 Luo, Z, Asojo, O. 登録日 2017-03-12 公開日 2017-08-30 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Crystal Structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa, the fungus that causes Witches' Broom Disease of Cacao. Sci Rep, 7, 2017
5IDP	CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone 分子名称: (3-amino-1H-indazol-5-yl)[(2S)-2-(4-fluorophenyl)piperidin-1-yl]methanone, Cyclin-C, Cyclin-dependent kinase 8, ... 著者 Musil, D, Blagg, J, Mallinger, A, Czodrowski, P, Schiemann, K. 登録日 2016-02-24 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. J. Med. Chem., 59, 2016
5UYX	Structure of Human T-complex protein 1 subunit epsilon (CCT5) 分子名称: ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit epsilon 著者 Pereira, J.H, McAndrew, R.P, Sergeeva, O.A, Ralston, C.Y, King, J.A, Adams, P.D. 登録日 2017-02-24 公開日 2017-07-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy. Sci Rep, 7, 2017
5V80	PIM1 kinase in complex with Cpd1 (1-methyl-4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)piperazin-2-one) 分子名称: 1-methyl-4-{3-[6-(piperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[3,4-c]pyridin-5-yl}piperazin-2-one, PHOSPHATE ION, Serine/threonine-protein kinase pim-1 著者 Murray, J.M, Wallweber, H. 登録日 2017-03-21 公開日 2018-04-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.252 Å) 主引用文献 Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J. Med. Chem., 60, 2017
3JS3	Crystal structure of type I 3-dehydroquinate dehydratase (aroD) from Clostridium difficile with covalent reaction intermediate 分子名称: 3-AMINO-4,5-DIHYDROXY-CYCLOHEX-1-ENECARBOXYLATE, 3-dehydroquinate dehydratase 著者 Minasov, G, Light, S.H, Shuvalova, L, Dubrovska, I, Winsor, J, Peterson, S.N, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2009-09-09 公開日 2009-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates. J.Biol.Chem., 286, 2011
3L0E	X-ray crystal structure of a Potent Liver X Receptor Modulator 分子名称: N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide, Nuclear receptor coactivator 2, Oxysterols receptor LXR-beta 著者 Gampe Jr, R.T. 登録日 2009-12-09 公開日 2010-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem., 53, 2010
1RHS	SULFUR-SUBSTITUTED RHODANESE 分子名称: SULFUR-SUBSTITUTED RHODANESE 著者 Zanotti, G, Gliubich, F, Colapietro, M, Barba, L. 登録日 1997-07-16 公開日 1998-01-21 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Structure of sulfur-substituted rhodanese at 1.36 A resolution. Acta Crystallogr.,Sect.D, 54, 1998
5VC0	Crystal structure of human CYP3A4 bound to ritonavir 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Sevrioukova, I. 登録日 2017-03-30 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5VCE	Crystal structure of the cysteine depleted CYP3A4 bound to ritonavir 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Sevrioukova, I. 登録日 2017-03-31 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5ISH	Crystal structure of mouse CARM1 in complex with inhibitor SA0765 分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... 著者 Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. 登録日 2016-03-15 公開日 2017-03-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.152 Å) 主引用文献 Crystal structure of mouse CARM1 in complex with inhibitor SA0765 To Be Published
5V50	Crystal Structure of MpPR-1i 分子名称: PR-1 protein 著者 Luo, Z, Asojo, O. 登録日 2017-03-12 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Crystal Structure of MpPR-1i, a SCP/TAPS protein from Moniliophthora perniciosa, the fungus that causes Witches' Broom Disease of Cacao. Sci Rep, 7, 2017
4WHW	Direct photocapture of bromodomains using tropolone chemical probes 分子名称: 1,2-ETHANEDIOL, 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, Bromodomain-containing protein 4 著者 Hett, E.C, Piatnitski Chekler, E.L, Basak, A, Bonin, P.D, Denny, R.A, Flick, A.C, Geoghegan, K.F, Liu, S, Pletcher, M.T, Robinson, R.P, Sahasrabudhe, P, Salter, S, Stock, I.A, Jones, L.H. 登録日 2014-09-23 公開日 2015-10-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.345 Å) 主引用文献 Direct photocapture of bromodomains using tropolone chemical probes To Be Published
1RLB	RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN 分子名称: RETINOIC ACID, RETINOL BINDING PROTEIN, TRANSTHYRETIN 著者 Monaco, H.L, Rizzi, M, Coda, A. 登録日 1995-02-20 公開日 1996-04-11 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science, 268, 1995
1RHF	Crystal Structure of human Tyro3-D1D2 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, Tyrosine-protein kinase receptor TYRO3, ... 著者 Heiring, C, Dahlback, B, Muller, Y.A. 登録日 2003-11-14 公開日 2004-03-23 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family. J.Biol.Chem., 279, 2004
4WHF	Crystal Structure of TR3 LBD in complex with 1-(3,4,5-trihydroxyphenyl)decan-1-one 分子名称: 1-(3,4,5-trihydroxyphenyl)decan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1 著者 Li, F.W, Cai, Q.X, Li, A.Z, Tian, X.Y, Wang, W.J, Wang, Y, Hou, P.P, Wu, Q, Lin, T.W. 登録日 2014-09-22 公開日 2015-09-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity Chem.Biol., 22, 2015
3KQY	Crystal Structure of hPNMT in Complex AdoHcy and 2-amino-1H-benzo[d]imidazol-7-ol 分子名称: 2-amino-1H-benzimidazol-7-ol, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Drinkwater, N, Martin, J.L. 登録日 2009-11-17 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010
3KRX	Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal) 分子名称: BALANOL, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tesmer, J.J.G, Tesmer, V.M. 登録日 2009-11-19 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J.Med.Chem., 53, 2010
3KQO	Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine 分子名称: 6-chloro-9H-purine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Drinkwater, N, Martin, J.L. 登録日 2009-11-17 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010
3KR1	Crystal Structure of hPNMT in Complex AdoHcy and 5-chloro-1H-benzo[d]imidazol-2-amine 分子名称: 6-chloro-1H-benzimidazol-2-amine, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Drinkwater, N, Martin, J.L. 登録日 2009-11-17 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431, 2010
1CRB	CRYSTALLOGRAPHIC STUDIES ON A FAMILY OF CELLULAR LIPOPHILIC TRANSPORT PROTEINS. REFINEMENT OF P2 MYELIN PROTEIN AND THE STRUCTURE DETERMINATION AND REFINEMENT OF CELLULAR RETINOL-BINDING PROTEIN IN COMPLEX WITH ALL-TRANS-RETINOL 分子名称: CADMIUM ION, CELLULAR RETINOL BINDING PROTEIN, RETINOL 著者 Cowan, S.W, Jones, T.A. 登録日 1993-02-10 公開日 1994-12-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystallographic studies on a family of cellular lipophilic transport proteins. Refinement of P2 myelin protein and the structure determination and refinement of cellular retinol-binding protein in complex with all-trans-retinol. J.Mol.Biol., 230, 1993

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