5VCE
Crystal structure of the cysteine depleted CYP3A4 bound to ritonavir
Summary for 5VCE
| Entry DOI | 10.2210/pdb5vce/pdb |
| Related | 5VC0 5VCC 5VCD 5VCG |
| Related PRD ID | PRD_001001 |
| Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR, ... (4 entities in total) |
| Functional Keywords | cytochrome p450, cyp3a4, monooxygenase, cysteine mutation, ritonavir, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 57009.00 |
| Authors | Sevrioukova, I. (deposition date: 2017-03-31, release date: 2017-05-31, Last modification date: 2023-10-04) |
| Primary citation | Sevrioukova, I.F. High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56:3058-3067, 2017 Cited by PubMed: 28590129DOI: 10.1021/acs.biochem.7b00334 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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