5V80

PIM1 kinase in complex with Cpd1 (1-methyl-4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)piperazin-2-one)

Summary for 5V80

Entry DOI	10.2210/pdb5v80/pdb
Descriptor	Serine/threonine-protein kinase pim-1, PHOSPHATE ION, 1-methyl-4-{3-[6-(piperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[3,4-c]pyridin-5-yl}piperazin-2-one, ... (4 entities in total)
Functional Keywords	pim1, sbdd, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34934.57
Authors	Murray, J.M.,Wallweber, H. (deposition date: 2017-03-21, release date: 2018-04-18, Last modification date: 2024-03-06)
Primary citation	Wang, X.,Kolesnikov, A.,Tay, S.,Chan, G.,Chao, Q.,Do, S.,Drummond, J.,Ebens, A.J.,Liu, N.,Ly, J.,Harstad, E.,Hu, H.,Moffat, J.,Munugalavadla, V.,Murray, J.,Slaga, D.,Tsui, V.,Volgraf, M.,Wallweber, H.,Chang, J.H. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J. Med. Chem., 60:4458-4473, 2017 Cited by PubMed: 28445037 DOI: 10.1021/acs.jmedchem.7b00418 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.252 Å)

Structure validation