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3KR1

Crystal Structure of hPNMT in Complex AdoHcy and 5-chloro-1H-benzo[d]imidazol-2-amine

Summary for 3KR1
Entry DOI10.2210/pdb3kr1/pdb
Related3KPJ 3KPU 3KPV 3KPW 3KPY 3KQM 3KQO 3KQP 3KQQ 3KQS 3KQT 3KQV 3KQW 3KQY 3KR0 3KR2
DescriptorPhenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 6-chloro-1H-benzimidazol-2-amine, ... (4 entities in total)
Functional Keywordsmethyltransferase, fragment screening, catecholamine biosynthesis, s-adenosyl-l-methionine, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight64795.95
Authors
Drinkwater, N.,Martin, J.L. (deposition date: 2009-11-17, release date: 2010-09-29, Last modification date: 2023-09-06)
Primary citationDrinkwater, N.,Vu, H.,Lovell, K.M.,Criscione, K.R.,Collins, B.M.,Prisinzano, T.E.,Poulsen, S.A.,McLeish, M.J.,Grunewald, G.L.,Martin, J.L.
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.
Biochem.J., 431:51-61, 2010
Cited by
PubMed: 20642456
DOI: 10.1042/BJ20100651
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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