3KQT
Crystal Structure of hPNMT in Complex AdoHcy and 2-Amino-1-methylbenzimidazole
Summary for 3KQT
Entry DOI | 10.2210/pdb3kqt/pdb |
Related | 3KPJ 3KPU 3KPV 3KPW 3KPY 3KQM 3KQO 3KQP 3KQQ 3KQS 3KQV 3KQW 3KQY 3KR0 3KR1 3KR2 |
Descriptor | Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 1-methyl-1H-benzimidazol-2-amine, ... (4 entities in total) |
Functional Keywords | methyltransferase, fragment screening, catecholamine biosynthesis, s-adenosyl-l-methionine, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 64755.11 |
Authors | Drinkwater, N.,Martin, J.L. (deposition date: 2009-11-17, release date: 2010-09-29, Last modification date: 2024-10-09) |
Primary citation | Drinkwater, N.,Vu, H.,Lovell, K.M.,Criscione, K.R.,Collins, B.M.,Prisinzano, T.E.,Poulsen, S.A.,McLeish, M.J.,Grunewald, G.L.,Martin, J.L. Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431:51-61, 2010 Cited by PubMed: 20642456DOI: 10.1042/BJ20100651 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.399 Å) |
Structure validation
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