PDB: 1828 件ウェブページステータス検索Chemie searchBIRD

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4NUF	Crystal Structure of SHP/EID1 分子名称: EID1 peptide, Maltose ABC transporter periplasmic protein, Nuclear receptor subfamily 0 group B member 2 chimeric construct, ... 著者 Zhi, X, Zhou, X.E, He, Y, Zechner, C, Suino-Powell, K.M, Kliewer, S.A, Melcher, K, Mangelsdorf, D.J, Xu, H.E. 登録日 2013-12-03 公開日 2014-01-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural insights into gene repression by the orphan nuclear receptor SHP. Proc.Natl.Acad.Sci.USA, 111, 2014
4NQA	Crystal structure of liganded hRXR-alpha/hLXR-beta heterodimer on DNA 分子名称: (9cis)-retinoic acid, 5'-D(*TP*AP*AP*GP*GP*TP*CP*AP*CP*TP*TP*CP*AP*GP*GP*TP*CP*A)-3', 5'-D(*TP*AP*TP*GP*AP*CP*CP*TP*GP*AP*AP*GP*TP*GP*AP*CP*CP*T)-3', ... 著者 Lou, X.H, Toresson, G, Benod, C, Suh, J.H, Phillips, K.J, Webb, P, Gustafsson, J.A. 登録日 2013-11-24 公開日 2014-02-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.102 Å) 主引用文献 Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA. Nat.Struct.Mol.Biol., 21, 2014
3WMH	Human PPAR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75 分子名称: N-(phenylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide, Peroxisome proliferator-activated receptor gamma 著者 Oyama, T, Ohashi, M, Miyachi, H, Kusunoki, M. 登録日 2013-11-19 公開日 2014-11-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Human PPRR gamma ligand binding domain in complex with a gammma selective synthetic partial agonist MEKT75 TO BE PUBLISHED
4NIE	Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand 分子名称: 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, N-(4-{[benzyl(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... 著者 Ma, Y.L, Yang, L.Q. 登録日 2013-11-06 公開日 2013-12-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 5, 2014
4NB6	Crystal structure of the ligand binding domain of RORC with T0901317 分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Nuclear receptor ROR-gamma 著者 Hymowitz, S.G, Boenig-de Leon, G. 登録日 2013-10-22 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. Bioorg.Med.Chem.Lett., 23, 2013
4N8R	Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 分子名称: 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha 著者 Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. 登録日 2013-10-17 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
4N73	Crystal structure of the ligand binding domain (LBD) of REV-ERB beta bound to Cobalt Protoporphyrin IX 分子名称: Nuclear receptor subfamily 1 group D member 2, PROTOPORPHYRIN IX CONTAINING CO 著者 Matta-Camacho, E, Kojetin, D. 登録日 2013-10-14 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8662 Å) 主引用文献 Structure of REV-ERB beta Ligand-binding Domain Bound to a Porphyrin Antagonist. J.Biol.Chem., 289, 2014
4N5G	Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 分子名称: 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha 著者 Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. 登録日 2013-10-09 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
3WJ4	Crystal structure of PPARgamma ligand binding domain in complex with tributyltin 分子名称: Peroxisome proliferator-activated receptor gamma, tributylstannanyl 著者 Harada, S, Hiromori, Y, Fukakusa, S, Kawahara, K, Nakamura, S, Noda, M, Uchiyama, S, Fukui, K, Nishikawa, J, Nagase, H, Kobayashi, Y, Ohkubo, T, Yoshida, T, Nakanishi, T. 登録日 2013-10-04 公開日 2014-10-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds To be Published
3WJ5	Crystal structure of PPARgamma ligand binding domain in complex with triphenyltin 分子名称: Peroxisome proliferator-activated receptor gamma, triphenylstannanyl 著者 Harada, S, Hiromori, Y, Fukakusa, S, Kawahara, K, Nakamura, S, Noda, M, Uchiyama, S, Fukui, K, Nishikawa, J, Nagase, H, Kobayashi, Y, Ohkubo, T, Yoshida, T, Nakanishi, T. 登録日 2013-10-04 公開日 2014-10-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds To be Published
4N1Y	Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain 分子名称: Estrogen receptor 著者 Ortlund, E.O. 登録日 2013-10-04 公開日 2014-02-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.605 Å) 主引用文献 Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. PLoS Genet, 10, 2014
4MG8	Crystal structure of hERa-LBD (Y537S) in complex with alpha-zearalanol 分子名称: 1,2-ETHANEDIOL, Estrogen receptor, GLYCEROL, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MGD	Crystal structure of hERa-LBD (Y537S) in complex with HPTE 分子名称: 1,2-ETHANEDIOL, 4,4'-(2,2,2-trichloroethane-1,1-diyl)diphenol, Estrogen receptor, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MGC	Crystal structure of hERa-LBD (Y537S) in complex with benzophenone-2 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG6	Crystal structure of hERa-LBD (Y537S) in complex with benzylbutylphtalate 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MGA	Crystal structure of hERa-LBD (Y537S) in complex with 4-tert-octylphenol 分子名称: 4-(2,4,4-trimethylpentan-2-yl)phenol, Estrogen receptor, Nuclear receptor coactivator 1 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG5	Crystal structure of hERa-LBD (Y537S) in complex with chlordecone 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MGB	Crystal structure of hERa-LBD (Y537S) in complex with TCBPA 分子名称: 4,4'-propane-2,2-diylbis(2,6-dichlorophenol), Estrogen receptor, GLYCEROL, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG9	Crystal structure of hERa-LBD (Y537S) in complex with butylparaben 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG7	Crystal structure of hERa-LBD (Y537S) in complex with ferutinine 分子名称: 1,2-ETHANEDIOL, Estrogen receptor, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MDD	Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12 分子名称: Glucocorticoid receptor, N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide, Nuclear receptor corepressor 1 著者 Coghlan, M.J, Luz, J.G. 登録日 2013-08-22 公開日 2014-12-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12 To be Published
4M8H	CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH (R)4-METHYL 9cUAB30 AND COACTIVATOR PEPTIDE GRIP-1 分子名称: (2E,6Z,8E)-3,7-dimethyl-8-[(4R)-4-methyl-3,4-dihydronaphthalen-1(2H)-ylidene]octa-2,6-dienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2013-08-13 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorg.Med.Chem., 22, 2014
4M8E	CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH (S) 4-Methyl 9cUAB30 COACTIVATOR PEPTIDE GRIP-1 分子名称: (3E,6Z,8E)-3,7-dimethyl-8-[(4S)-4-methyl-3,4-dihydronaphthalen-1(2H)-ylidene]octa-3,6-dienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2013-08-13 公開日 2014-01-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorg.Med.Chem., 22, 2014
3WGP	Crystal Structure Analysis of Vitamin D receptor 分子名称: (1R,2R,3R,5Z,7E,14beta,17alpha)-2-(3-hydroxypropoxy)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, Vitamin D3 receptor 著者 Itoh, S, Iijima, S. 登録日 2013-08-07 公開日 2014-08-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure Analysis of Vitamin D receptor to be published
4LSJ	Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide 分子名称: D30 peptide, Glucocorticoid receptor, N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide 著者 Carson, M, Luz, J.G, Clawson, D, Coghlan, M. 登録日 2013-07-22 公開日 2014-01-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design. J.Med.Chem., 57, 2014

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