4N8R
Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008
Summary for 4N8R
Entry DOI | 10.2210/pdb4n8r/pdb |
Related | 4N5G |
Descriptor | Retinoic acid receptor RXR-alpha, 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole (3 entities in total) |
Functional Keywords | retinoid x receptor, alpha nuclear receptor, nucleus, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P19793 |
Total number of polymer chains | 4 |
Total formula weight | 109790.98 |
Authors | Aleshin, A.E.,Su, Y.,Zhang, X.,Liddington, R.C. (deposition date: 2013-10-17, release date: 2014-05-14, Last modification date: 2023-09-20) |
Primary citation | Chen, L.,Wang, Z.G.,Aleshin, A.E.,Chen, F.,Chen, J.,Jiang, F.,Alitongbieke, G.,Zeng, Z.,Ma, Y.,Huang, M.,Zhou, H.,Cadwell, G.,Zheng, J.F.,Huang, P.Q.,Liddington, R.C.,Zhang, X.K.,Su, Y. Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21:596-607, 2014 Cited by PubMed: 24704507DOI: 10.1016/j.chembiol.2014.02.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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