4NB6

Crystal structure of the ligand binding domain of RORC with T0901317

Summary for 4NB6

Entry DOI	10.2210/pdb4nb6/pdb
Related	1PQ9 1PQC 2O91
Descriptor	Nuclear receptor ROR-gamma, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE (3 entities in total)
Functional Keywords	alpha-helical, transcription factor, nucleus, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Probable): P51449
Total number of polymer chains	2
Total formula weight	59045.75
Authors	Hymowitz, S.G.,Boenig-de Leon, G. (deposition date: 2013-10-22, release date: 2013-11-27, Last modification date: 2023-09-20)
Primary citation	Fauber, B.P.,de Leon Boenig, G.,Burton, B.,Eidenschenk, C.,Everett, C.,Gobbi, A.,Hymowitz, S.G.,Johnson, A.R.,Liimatta, M.,Lockey, P.,Norman, M.,Ouyang, W.,Rene, O.,Wong, H. Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. Bioorg.Med.Chem.Lett., 23:6604-6609, 2013 Cited by PubMed: 24239186 DOI: 10.1016/j.bmcl.2013.10.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation