4LSJ

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide

Summary for 4LSJ

Entry DOI	10.2210/pdb4lsj/pdb
Descriptor	Glucocorticoid receptor, D30 peptide, N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide, ... (4 entities in total)
Functional Keywords	nuclear hormone receptor, transcription
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm. Isoform Beta: Nucleus: P04150
Total number of polymer chains	2
Total formula weight	32388.69
Authors	Carson, M.,Luz, J.G.,Clawson, D.,Coghlan, M. (deposition date: 2013-07-22, release date: 2014-01-29, Last modification date: 2024-02-28)
Primary citation	Carson, M.W.,Luz, J.G.,Suen, C.,Montrose, C.,Zink, R.,Ruan, X.,Cheng, C.,Cole, H.,Adrian, M.D.,Kohlman, D.T.,Mabry, T.,Snyder, N.,Condon, B.,Maletic, M.,Clawson, D.,Pustilnik, A.,Coghlan, M.J. Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design. J.Med.Chem., 57:849-860, 2014 Cited by PubMed: 24446728 DOI: 10.1021/jm401616g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation