4LSJ
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glucocorticoid receptor | polymer | 258 | 29942.8 | 1 | UniProt (P04150) Pfam (PF00104) In PDB | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
2 | B | D30 peptide | polymer | 13 | 1574.8 | 1 | |||
3 | A | N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide | non-polymer | 435.5 | 2 | Chemie (LSJ) | |||
4 | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 522 - 777 (UniProt: P04150)
PDB | External Database | Details |
---|---|---|
Ser 520 | - | expression tag |
Leu 521 | - | expression tag |
Tyr 602 | Phe 602 | engineered mutation |
Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 31517.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 871.1 | |
All* | Total formula weight | 32388.7 |