4LSJ
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 258 | 29942.8 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | D30 peptide | polymer | 13 | 1574.8 | 1 | |||
| 3 | C, D (A) | N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide | non-polymer | 435.5 | 2 | Chemie (LSJ) | |||
| 4 | E (A) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 522 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 520 | - | expression tag |
| Leu 521 | - | expression tag |
| Tyr 602 | Phe 602 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31517.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 871.1 | |
| All* | Total formula weight | 32388.7 |
