2Y3W
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6DMB
| Cryo-EM structure of human Ptch1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Yan, N, Gong, X, Qian, H.W. | 登録日 | 2018-06-04 | 公開日 | 2018-07-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361, 2018
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6DB3
| JAK3 with Cyanamide CP23 | 分子名称: | Tyrosine-protein kinase JAK3, [(1S)-1-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | 著者 | Vajdos, F.F. | 登録日 | 2018-05-02 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J. Med. Chem., 61, 2018
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6DBE
| Crystal Structure of VHH R330 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, nanobody VHH R303 | 著者 | Brooks, C.L, Toride King, M, Huh, I. | 登録日 | 2018-05-03 | 公開日 | 2018-07-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural basis of VHH-mediated neutralization of the food-borne pathogenListeria monocytogenes. J. Biol. Chem., 293, 2018
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5DH4
| PDE10 complexed with 5-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine | 分子名称: | 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione, 5-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine, MAGNESIUM ION, ... | 著者 | Yan, Y. | 登録日 | 2015-08-29 | 公開日 | 2016-01-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg.Med.Chem.Lett., 26, 2016
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3HF8
| Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe | 分子名称: | 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Tari, L.W, Swanson, R.V, Hunter, M.J. | 登録日 | 2009-05-11 | 公開日 | 2010-04-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4, 2010
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5D1R
| Crystal structure of Mycobacterium tuberculosis Rv1816 transcriptional regulator. | 分子名称: | MAGNESIUM ION, NICKEL (II) ION, Rv1816 transcriptional regulator, ... | 著者 | Chou, T.-H, Delmar, J, Su, C.-C, Yu, E. | 登録日 | 2015-08-04 | 公開日 | 2015-09-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis. J.Biol.Chem., 290, 2015
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3HE5
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6ZFG
| 14-3-3 zeta chimera with 18E6 and fusicoccin | 分子名称: | 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL | 著者 | Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. | 登録日 | 2020-06-17 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
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2G82
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2G3M
| Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA | 分子名称: | Alpha-glucosidase | 著者 | Ernst, H.A, Lo Leggio, L, Willemoes, M, Leonard, G, Blum, P, Larsen, S. | 登録日 | 2006-02-20 | 公開日 | 2006-05-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of the Sulfolobus solfataricus alpha-Glucosidase: Implications for Domain Conservation and Substrate Recognition in GH31. J.Mol.Biol., 358, 2006
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5D3D
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3HF2
| Crystal structure of the I401P mutant of cytochrome P450 BM3 | 分子名称: | Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Yang, W, Whitehouse, C.J.C, Bell, S.G, Bartlam, M, Wong, L.L, Rao, Z. | 登録日 | 2009-05-10 | 公開日 | 2009-06-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A Highly Active Single-Mutation Variant of P450(BM3) (CYP102A1) Chembiochem, 10, 2009
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6D4O
| Eubacterium eligens beta-glucuronidase bound to an amoxapine-glucuronide conjugate | 分子名称: | (5aR,9aR)-2-chloro-11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5a,6,9,9a-tetrahydrodibenzo[b,f][1,4]oxazepine, Beta-glucuronidase, CHLORIDE ION, ... | 著者 | Pellock, S.J, Walton, W.G, Redinbo, M.R. | 登録日 | 2018-04-18 | 公開日 | 2018-07-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Gut Microbial beta-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci, 4, 2018
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3HH4
| New azaborine compounds bind to the T4 lysozyme L99A cavity - Benzene as control | 分子名称: | 2-HYDROXYETHYL DISULFIDE, BENZENE, Lysozyme, ... | 著者 | Liu, L, Matthews, B.W. | 登録日 | 2009-05-14 | 公開日 | 2009-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Boron mimetics: 1,2-dihydro-1,2-azaborines bind inside a nonpolar cavity of T4 lysozyme. Angew.Chem.Int.Ed.Engl., 48, 2009
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6DDT
| mouse beta-mannosidase (MANBA) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gytz, H, Liang, J, Liang, Y, Gorelik, A, Illes, K, Nagar, B. | 登録日 | 2018-05-10 | 公開日 | 2019-01-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structure of mammalian beta-mannosidase provides insight into beta-mannosidosis and nystagmus. FEBS J., 286, 2019
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3HFS
| Structure of apo anthocyanidin reductase from vitis vinifera | 分子名称: | Anthocyanidin reductase, CHLORIDE ION | 著者 | Gargouri, M, Mauge, C, Langlois d'Estaintot, B, Granier, T, Manigan, C, Gallois, B. | 登録日 | 2009-05-12 | 公開日 | 2009-09-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | Structure and epimerase activity of anthocyanidin reductase from Vitis vinifera. Acta Crystallogr.,Sect.D, 65, 2009
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3HG3
| Human alpha-galactosidase catalytic mechanism 2. Substrate bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | 著者 | Guce, A.I, Clark, N.E, Garman, S.C. | 登録日 | 2009-05-13 | 公開日 | 2009-11-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Catalytic mechanism of human alpha-galactosidase. J.Biol.Chem., 285, 2010
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5D9T
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2GC3
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5D9X
| Dehydroascorbate reductase complexed with GSH | 分子名称: | CALCIUM ION, Dehydroascorbate reductase, GLUTATHIONE | 著者 | Do, H, Lee, J.H. | 登録日 | 2015-08-19 | 公開日 | 2016-02-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Structural understanding of the recycling of oxidized ascorbate by dehydroascorbate reductase (OsDHAR) from Oryza sativa L. japonica Sci Rep, 6, 2016
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3HHY
| Crystal structure determination of Catechol 1,2-Dioxygenase from Rhodococcus opacus 1CP in complex with catechol | 分子名称: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, CATECHOL, CHLORIDE ION, ... | 著者 | Matera, I, Ferraroni, M, Kolomytseva, M, Briganti, F, Scozzafava, A. | 登録日 | 2009-05-18 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts. J.Struct.Biol., 170, 2010
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6D6G
| Triclinic lysozyme (295 K) in the presence of 47% MPD | 分子名称: | Lysozyme C, NITRATE ION | 著者 | Juers, D.H. | 登録日 | 2018-04-20 | 公開日 | 2018-09-19 | 最終更新日 | 2020-01-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order. Acta Crystallogr D Struct Biol, 74, 2018
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2Y0D
| BceC mutation Y10K | 分子名称: | SULFATE ION, UDP-GLUCOSE DEHYDROGENASE, URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID | 著者 | Rocha, J, Popescu, A.O, Borges, P, Mil-Homens, D, Sa-Correia, I, Fialho, A.M, Frazao, C. | 登録日 | 2010-12-02 | 公開日 | 2011-07-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of Burkholderia Cepacia Udp-Glucose Dehydrogenase (Ugd) Bcec and Role of Tyr10 in Final Hydrolysis of Ugd Thioester Intermediate. J.Bacteriol., 193, 2011
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3HEI
| Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex | 分子名称: | Ephrin type-A receptor 2, Ephrin-A1 | 著者 | Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B. | 登録日 | 2009-05-08 | 公開日 | 2009-06-30 | 最終更新日 | 2021-03-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. Embo Rep., 10, 2009
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